{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T10:24:21Z","timestamp":1780568661392,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:00:00Z","timestamp":1709078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Rectal hyposensitivity (RH) is common in constipation and often coexists with functional defecatory disorder (FDD). Rectal sensory thresholds are routinely evaluated with the anorectal manometry probe; however, the gold standard for the assessment of rectal sensitivity is with a barostat, use of which is limited by time constraints and availability. A novel rapid barostat bag (RBB) may facilitate measurements of rectal sensitivity. The aim is to evaluate the relationship between RH (measured by the RBB) and FDD (defined as any minor disorder of rectoanal coordination by the London classification) in constipated patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive constipated patients referred for anorectal function testing underwent anorectal manometry with the 3D\u2010HDAM probe as well as rectal sensation testing with the RBB pump. RH was defined by volume to first sensation &gt;30%, urge to defecate &gt;80%, or discomfort &gt;100% (normalized to rectal capacity).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010three percent of constipated patients had RH. Patients with FDD had a significantly increased volume to first sensation (134.5\u00a0mL <jats:italic>vs<\/jats:italic> 102.0, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02), urge to defecate (187.0\u00a0mL <jats:italic>vs<\/jats:italic> 149.0, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04), and rectal capacity (253.5\u00a0mL <jats:italic>vs<\/jats:italic> 209.0, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04) compared to constipated patients without FDD. There was no difference in normalized sensory thresholds (percent of rectal capacity) nor the prevalence of hyposensitivity to each sensory threshold nor overall hyposensitivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with FDD, when measured with the RBB, have increased sensory thresholds on volumetric distension, but RH was not observed when sensory threshold volume were normalized to rectal capacity. This may reflect \u201csecondary\u201d RH due to altered rectal biomechanics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16517","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T03:48:33Z","timestamp":1709178513000},"page":"1082-1087","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Constipated patients with functional defecatory disorder have secondary rectal hyposensitivity due to altered rectal biomechanics"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4487-3420","authenticated-orcid":false,"given":"Matthew","family":"Woo","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Calgary Cumming School of Medicine  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armaan","family":"Pandey","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Calgary Cumming School of Medicine  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothy","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Calgary Cumming School of Medicine  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Buresi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Calgary Cumming School of Medicine  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2081-0348","authenticated-orcid":false,"given":"Yasmin","family":"Nasser","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Calgary Cumming School of Medicine  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher N","family":"Andrews","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Calgary Cumming School of Medicine  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,28]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"758","article-title":"Clinical impact of rectal hyposensitivity","author":"Vollebregt PF","year":"2020","journal-title":"Am. 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