{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T17:32:26Z","timestamp":1774027946867,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Gastrointestinal stromal tumors (GISTs) are treated as malignant gastric subepithelial lesions (SELs), and resection is recommended. However, small gastric SELs &lt;\u00a020\u00a0mm with no malignant features are monitored without histopathological examination, and the frequency of malignancy is unknown. This study aimed to clarify the clinicopathological findings and clinical course of gastric SELs &lt;\u00a020\u00a0mm measured by endoscopic ultrasound (EUS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study included consecutive patients with small gastric SELs &lt;\u00a020\u00a0mm diagnosed using EUS at a tertiary referral center between 2009 and 2021. The clinical course after diagnosis using EUS\u2010guided fine\u2010needle aspiration (EUS\u2010FNA) was reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 333 patients with small gastric SELs, 104 patients with 105 lesions underwent EUS\u2010FNA. The pathological diagnosis was confirmed in 87 patients. GISTs were the most common pathology (47%). Among the 87 patients, 43 underwent therapeutic interventions, including tumor resection and chemotherapy. In groups of tumor resection, the pathological tumor size on the resected specimen was significantly larger than the size measured by EUS (19.5\u00a0mm <jats:italic>vs<\/jats:italic> 15.0\u00a0mm, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), and 37% of resected SELs were 20\u00a0mm or over. No recurrence was observed after tumor resection during a mean follow\u2010up period of 40\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Approximately 40% of small gastric SELs were malignant tumors, such as GIST, with most of them requiring treatment. Additionally, considering that the EUS measurement is 5\u00a0mm smaller than the pathological tumor diameter, further examinations, such as systematic EUS\u2010FNA, may be required for SEL, including those smaller than 20\u00a0mm.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16534","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T10:47:01Z","timestamp":1709808421000},"page":"1285-1290","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinical course of small gastric subepithelial lesion less than 20\u00a0mm diagnosed by endoscopic ultrasound\u2010guided fine\u2010needle aspiration"],"prefix":"10.1111","volume":"39","author":[{"given":"Ryosuke","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Division of Endoscopy Yokohama City University Medical Center  Yokohama 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