{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T16:58:32Z","timestamp":1785344312943,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:00:00Z","timestamp":1712793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Linked color imaging (LCI) is an image\u2010enhanced endoscopy technique that accentuates the color difference between red and white, potentially improving the adenoma detection rate (ADR). However, it remains unclear whether LCI performance in detecting colorectal lesions differs based on endoscopists' experience levels. We aimed to evaluate the differences in LCI efficacy based on the experience levels of endoscopists by conducting an exploratory analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this post hoc analysis of an international randomized controlled trial comparing the detection of adenoma and other lesions using colonoscopy with LCI and high\u2010definition white light imaging (WLI), we included patients from 11 institutions across four countries\/regions: Japan, Thailand, Taiwan, and Singapore. We retrospectively reviewed differences in the lesion detection of LCI according to endoscopists' colonoscopy history or ADR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 1692 and 1138 patients who underwent colonoscopies performed by 54 experts (experience of \u2265\u00a05000 colonoscopies) and by 43 non\u2010experts (experience of &lt;\u00a05000 colonoscopies), respectively. Both expert and non\u2010expert groups showed a significant improvement in ADR with LCI compared to WLI (expert, 61.7% <jats:italic>vs<\/jats:italic> 46.4%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001; non\u2010expert, 56.6% <jats:italic>vs<\/jats:italic> 46.4%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). LCI had no effect on sessile serrated lesion detection rate in non\u2010experts (3.1% <jats:italic>vs<\/jats:italic> 2.5%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.518). LCI significantly improved detection rates in endoscopists with relatively low detection performance, defined as an ADR\u00a0&lt;\u00a050%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This exploratory study analyzed data from a previous trial and revealed that LCI is useful for both experts and non\u2010experts and is even more beneficial for endoscopists with relatively low detection performance using WLI.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16576","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T11:59:02Z","timestamp":1712836742000},"page":"1374-1381","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Linked color imaging improves colorectal lesion detection especially for low performance endoscopists: An international trial in Asia"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7726-4061","authenticated-orcid":false,"given":"Issei","family":"Hasegawa","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4831-1409","authenticated-orcid":false,"given":"Sho","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology International University of Health and Welfare, School of Medicine  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Yamamura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satmai","family":"Aniwan","sequence":"additional","affiliation":[{"name":"Center of Excellence in Endoscopy for Gastrointestinal Oncology, Department of Medicine, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2786-8056","authenticated-orcid":false,"given":"Han\u2010Mo","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kannikar","family":"Laohavichitra","sequence":"additional","affiliation":[{"name":"Rajavithi Digestive Endoscopy Center Rajavithi Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakkarin","family":"Chirapongsathorn","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology and Hepatology Phramongkutklao Hospital and College of Medicine  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen\u2010Ya","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Fu Jen Catholic University Hospital  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6167-9705","authenticated-orcid":false,"given":"Naohisa","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9993-8549","authenticated-orcid":false,"given":"Tiing Leong","family":"Ang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Changi General Hospital  SingHealth Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahito","family":"Takezawa","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology Jichi Medical University  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6866-6886","authenticated-orcid":false,"given":"Rungsun","family":"Rerknimitr","sequence":"additional","affiliation":[{"name":"Center of Excellence in Endoscopy for Gastrointestinal Oncology, Department of Medicine, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Molecular\u2010Targeting Cancer Prevention Kyoto Prefectural University of Medicine  Kyoto 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