{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T11:54:32Z","timestamp":1784202872212,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T00:00:00Z","timestamp":1713571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012832","name":"Okinaka Memorial Institute for Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012832","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Since the first report of gastric adenocarcinoma of the fundic\u2010gland type in 2010, the clinicopathological characteristics of gastric neoplasm of the fundic\u2010gland type (GNFG) have become clearer; however, their risk factors remain unclear. This exploratory study aimed to identify the risk factors for GNFG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a single\u2010center, retrospective, matched case\u2013control study using medical information recorded at our health management center from January 2014 to July 2023. During this period, 39\u00a0240 people underwent upper gastrointestinal endoscopy. GNFG were extracted as cases and matched to controls, according to age and sex, in a 1:8 ratio, excluding those with a history of gastrointestinal surgery and those with a history or comorbidity of cancer. Univariate analysis was used to compare patient background and endoscopic findings. Multivariable analysis was performed, adjusting for factors with <jats:italic>P<\/jats:italic> values &lt;\u00a00.1 and antacid use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 20 GNFG cases and 160 matched healthy controls were included. In the univariate analysis, only reflux esophagitis was significantly more common in GNFG (40.0% <jats:italic>vs<\/jats:italic> 18.1%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.036). Factors antacids and duodenitis had <jats:italic>P<\/jats:italic> values &lt;\u00a00.1. Logistic regression analysis was performed, adjusting for antacids, reflux esophagitis, and duodenitis. Antacids and reflux esophagitis were the independent risk factors for GNFG (odds ratio\u00a0=\u00a03.68 [95% confidence interval: 1.04\u201311.91] and 3.25 [95% confidence interval: 1.11\u20139.35]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although the sample of patients with GNFG was small, antacids and reflux esophagitis were identified as a risk factor. The pathogenesis of antacids and reflux esophagitis may be involved in the development of GNFG.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16577","type":"journal-article","created":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T09:09:10Z","timestamp":1713604150000},"page":"1580-1585","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Antacids and reflux esophagitis as a risk factor for gastric neoplasm of fundic\u2010gland type: A retrospective, matched case\u2013control study"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5501-3787","authenticated-orcid":false,"given":"Junnosuke","family":"Hayasaka","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Toranomon Hospital  Tokyo Japan"},{"name":"Okinaka Memorial Institute for Medical Research  Tokyo 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