{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T05:03:51Z","timestamp":1783141431114,"version":"3.54.6"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>This study estimated the prevalence of metabolic dysfunction\u2010associated steatotic liver disease (MASLD) according to cardiometabolic risk factors. The long\u2010term impacts of MASLD on all\u2010cause and cardiometabolic\u2010specific mortality were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 343\u2009816 adults aged \u226530\u00a0years who participated in a health screening program from 1997 through 2013. MASLD was identified on the basis of abdominal ultrasonography and metabolic profiles. The participants were further categorized by liver enzyme elevation. Baseline cardiometabolic comorbidities were classified on the basis of self\u2010reported medication use and clinical seromarkers. All\u2010cause and cardiometabolic\u2010specific deaths were determined through computerized data linkage with nationwide death certifications until December 31, 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall prevalence of MASLD was 36.4%. Among patients with MASLD, 35.9% had abnormal liver enzyme levels. Compared with patients without MASLD, abnormal liver enzymes were positively associated with cardiometabolic comorbidities in patients with MASLD (<jats:italic>P<\/jats:italic><jats:sub><jats:italic>for trend<\/jats:italic><\/jats:sub>\u00a0&lt;\u00a00.001). After follow\u2010up, patients with MASLD had a 9%\u201329% higher risk of all\u2010cause, cardiovascular\u2010related, or diabetes\u2010related mortality. In the groups with MASLD and elevated and normal liver enzyme levels, the multivariate\u2010adjusted hazard ratios for cardiovascular deaths were 1.14 (1.05\u20131.25) and 1.10 (1.03\u20131.17), respectively, and those for diabetes deaths were 1.42 (1.05\u20131.93) and 1.24 (0.98\u20131.57), respectively, compared with those in the non\u2010MASLD group (<jats:italic>P<\/jats:italic><jats:sub><jats:italic>for trend<\/jats:italic><\/jats:sub>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Individuals with MASLD and elevated liver enzyme levels exhibited significantly higher risks of all\u2010cause and cardiometabolic deaths and should be monitored and given consultation on cardiometabolic modifications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16592","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T06:33:54Z","timestamp":1715322834000},"page":"1939-1949","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Prevalence, proportions of elevated liver enzyme levels, and long\u2010term cardiometabolic mortality of patients with metabolic dysfunction\u2010associated steatotic liver disease"],"prefix":"10.1111","volume":"39","author":[{"given":"Yi\u2010Ting","family":"Chen","sequence":"first","affiliation":[{"name":"Institute of Clinical Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu\u2010I","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine National Yang Ming Chiao Tung University  Taipei 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