{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T12:39:47Z","timestamp":1791722387387,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Our study evaluated the outcomes of switching from tenofovir disoproxil fumarate (TDF) to tenofovir alafenamide (TAF) in patients with chronic hepatitis B (CHB). We assessed viral and biochemical responses as well as changes in the estimated glomerular filtration rate (eGFR) and bone mineral density (BMD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective multicenter study included CHB patients who achieved virologic response (VR) (HBV DNA\u00a0&lt;\u00a020\u00a0IU\/mL) while on TDF and were subsequently switched to TAF between April 2018 and October 2021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This study included 309 patients with a median age of 59\u00a0years, and 42.1% were male. The mean duration of TDF and TAF administration were 54.0 and 37.5\u00a0months, respectively. All patients maintained VR after switching to TAF. Alanine aminotransferase (ALT) normalization rate significantly increased 6\u00a0months after switching (74.8%\u201383.5%;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.008). Adjusted eGFR significantly improved at 6\u00a0months (+5.55\u00a0\u00b1\u00a010.52\u00a0mL\/min\/1.73\u00a0m\n                      <jats:sup>2<\/jats:sup>\n                      ;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and 12\u00a0months (+6.02\u00a0\u00b1\u00a010.70\u00a0mL\/min\/1.73\u00a0m\n                      <jats:sup>2<\/jats:sup>\n                      ;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) after switching. In the subgroup of patients with renal impairment (eGFR\u00a0&lt;\u00a060\u00a0mL\/min\/1.73\u00a0m\n                      <jats:sup>2<\/jats:sup>\n                      ), significant improvement in renal function was observed at 6\u00a0months (+0.6\u00a0\u00b1\u00a010.5\u00a0mL\/min\/1.73\u00a0m\n                      <jats:sup>2<\/jats:sup>\n                      ;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and 12\u00a0months (+1.0\u00a0\u00b1\u00a010.7\u00a0mL\/min\/1.73\u00a0m\n                      <jats:sup>2<\/jats:sup>\n                      ;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) after switching to TAF. In patients with osteoporosis (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0182), switching to TAF resulted in significant improvement in spine and hip BMD at 12\u00a0months, with increases of 9.7% (95% CI: 7.0\u201312.5) and 9.4% (95% CI: 7.0\u201311.8), respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this real\u2010world study, switching to TAF was effective and safe in patients, with notable improvements in ALT levels, renal function, and BMD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.16593","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T05:35:25Z","timestamp":1714541725000},"page":"1673-1683","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Switching from tenofovir disoproxil fumarate to tenofovir alafenamide in virologically suppressed patient with chronic hepatitis B"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5421-6868","authenticated-orcid":false,"given":"Heechul","family":"Nam","sequence":"first","affiliation":[{"name":"The Catholic University Liver Research Center, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"},{"name":"Division of Hepatology, Department of Internal Medicine, Uijeongbu St. Mary's Hospital, College of Medicine The Catholic University of Korea  Bucheon\u2010si Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Won","family":"Han","sequence":"additional","affiliation":[{"name":"The Catholic University Liver Research Center, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"},{"name":"Division of Hepatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1865-8225","authenticated-orcid":false,"given":"Soon Kyu","family":"Lee","sequence":"additional","affiliation":[{"name":"The Catholic University Liver Research Center, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"},{"name":"Division of Hepatology, Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine The Catholic University of Korea  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun","family":"Yang","sequence":"additional","affiliation":[{"name":"The Catholic University Liver Research Center, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"},{"name":"Division of Hepatology, Department of Internal Medicine, Eunpyeong St. Mary's Hospital, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae Lim","family":"Lee","sequence":"additional","affiliation":[{"name":"The Catholic University Liver Research Center, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"},{"name":"Division of Hepatology, Department of Internal Medicine, Bucheon St. Mary's Hospital, College of Medicine The Catholic University of Korea  Bucheon\u2010si Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5780-9607","authenticated-orcid":false,"given":"Pil Soo","family":"Sung","sequence":"additional","affiliation":[{"name":"The Catholic University Liver Research Center, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"},{"name":"Division of Hepatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5244-0372","authenticated-orcid":false,"given":"Myeong Jun","family":"Song","sequence":"additional","affiliation":[{"name":"The Catholic University Liver Research Center, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"},{"name":"Division of Hepatology, Department of Internal Medicine, Daejeon St. Mary's Hospital, College of Medicine The Catholic University of Korea  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5484-5864","authenticated-orcid":false,"given":"Jung Hyun","family":"Kwon","sequence":"additional","affiliation":[{"name":"The Catholic University Liver Research Center, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"},{"name":"Division of Hepatology, Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine The Catholic University of Korea  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3255-8474","authenticated-orcid":false,"given":"Jeong Won","family":"Jang","sequence":"additional","affiliation":[{"name":"The Catholic University Liver Research Center, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"},{"name":"Division of Hepatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U\u2010Im","family":"Chang","sequence":"additional","affiliation":[{"name":"The Catholic University Liver Research Center, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"},{"name":"Division of Hepatology, Department of Internal Medicine, St. Vincent's Hospital, College of Medicine The Catholic University of Korea  Bucheon\u2010si Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Wook","family":"Kim","sequence":"additional","affiliation":[{"name":"The Catholic University Liver Research Center, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"},{"name":"Division of Hepatology, Department of Internal Medicine, Uijeongbu St. Mary's Hospital, College of Medicine The Catholic University of Korea  Bucheon\u2010si Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon Woo","family":"Nam","sequence":"additional","affiliation":[{"name":"The Catholic University Liver Research Center, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"},{"name":"Division of Hepatology, Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine The Catholic University of Korea  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si Hyun","family":"Bae","sequence":"additional","affiliation":[{"name":"The Catholic University Liver Research Center, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"},{"name":"Division of Hepatology, Department of Internal Medicine, Eunpyeong St. Mary's Hospital, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Young","family":"Choi","sequence":"additional","affiliation":[{"name":"The Catholic University Liver Research Center, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"},{"name":"Division of Hepatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Kew","family":"Yoon","sequence":"additional","affiliation":[{"name":"The Catholic University Liver Research Center, 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