{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:13:06Z","timestamp":1787015586205,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Several reports show a significant association between metabolic dysfunction\u2010associated steatotic liver disease (MASLD) and arterial stiffness (estimated pulse wave velocity [ePWV]) as a surrogate marker of vascular age. We investigate whether ePWV as arterial stiffness in MASLD is associated with all\u2010cause\/cause\u2010specific mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cohort study was based on the third National Health and Nutrition Examination Survey (NHANES, 1988\u20131994) and NHANES 2007\u20132014 and linked mortality datasets through 2019. Cox regression models assessed the association between ePWV categorized by quartile and all\u2010cause\/cause\u2010specific mortality among individuals with MASLD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During the follow\u2010up of a median of 26.3 years (interquartile range: 19.9\u201327.9), higher levels of ePWV among individuals with MASLD were associated with increased all\u2010cause mortality, which remained significant after adjusting for demographic, lifestyle, clinical, and metabolic risk factors. Furthermore, higher ePWV in MASLD was associated with higher cardiovascular mortality. There was a 44% (hazard ratio: 1.44, 95% confidence interval: 1.32\u20131.58) increase in all\u2010cause mortality and a 53% (hazard ratio: 1.53, 95% confidence interval: 1.32\u20131.77) increase in cardiovascular mortality for every 1 m\/s increase in ePWV in MASLD. However, there was no significant association between ePWV and cancer\u2010related mortality. Sensitivity analyses using the NHANES 2007\u20132014 dataset showed results identical to the original analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Higher ePWV in MASLD was associated with a higher risk of all\u2010cause and cardiovascular mortality beyond traditional cardiovascular risk factors. Screening for ePWV in individuals with MASLD may be an effective and beneficial approach to reducing all\u2010cause and cardiovascular mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.16608","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T21:14:16Z","timestamp":1715634856000},"page":"1950-1956","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Estimated pulse wave velocity in metabolic dysfunction\u2010associated steatotic liver disease and all\u2010cause\/cause\u2010specific mortality"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1919-6800","authenticated-orcid":false,"given":"Donghee","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7348-8081","authenticated-orcid":false,"given":"Richie","family":"Manikat","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6232-6343","authenticated-orcid":false,"given":"Karn","family":"Wijarnpreecha","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology and Hepatology University of Arizona College of Medicine  Phoenix Arizona USA"},{"name":"Department of Internal Medicine, Division of Gastroenterology and Hepatology Banner University Medical Center  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5335-8426","authenticated-orcid":false,"given":"George","family":"Cholankeril","sequence":"additional","affiliation":[{"name":"Liver Center, Division of Abdominal Transplantation, Michael E DeBakey Department of General Surgery Baylor College of Medicine  Houston Texas USA"},{"name":"Section of Gastroenterology and Hepatology, Department of Medicine Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3609-8586","authenticated-orcid":false,"given":"Aijaz","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl20127"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl19069"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.555235"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000909"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000654"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26156"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.07.035"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2022.0351"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.21037\/hbsn-21-571"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2009.08.002"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq165"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000935"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.12831"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31158"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.06.003"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.12.041"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0280896"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487320920767"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/geroni\/igac056"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000453073"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-021-06478-8"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.155"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30226"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.16608","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T21:40:50Z","timestamp":1746049250000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.16608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,13]]},"references-count":23,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/jgh.16608"],"URL":"https:\/\/doi.org\/10.1111\/jgh.16608","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,13]]},"assertion":[{"value":"2024-02-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}