{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T02:12:33Z","timestamp":1789524753289,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T00:00:00Z","timestamp":1715472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["201940082"],"award-info":[{"award-number":["201940082"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Several meta\u2010analyses have analyzed the technical and clinical success of endoscopic ultrasound\u2010guided choledochoduodenostomy (EUS\u2010CDS) by using lumen\u2010apposing metal stents (LAMS) in malignant biliary obstruction, but those concerning adverse events (AEs) are scarce. The current systematic review and meta\u2010analysis was conducted to evaluate the AEs after EUS\u2010CDS with LAMS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive literature search of PubMed, Embase, Scopus, Web of Science, and the Cochrane Library was conducted for studies reporting the outcomes of EUS\u2010CDS with LAMS. The main endpoints were the incidence of overall and specific AEs. Moreover, the stent dysfunction, and reintervention rates were evaluated independently.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 21 studies (<jats:italic>n<\/jats:italic>\u00a0=\u00a01438) were included in the final meta\u2010analysis. The pooled rate of technical and clinical success was 93.5% (95% confidence interval [CI]: 91.3\u201395.1) and 88.0% (95% CI: 83.9\u201391.1), respectively. After EUS\u2010CDS with LAMS, the pooled incidence of overall AEs was 20.1% (95% CI: 16.0\u201324.9). The estimated rate of early AEs was 10.6% (95% CI: 7.9\u201314.2), and late AEs was 11.2% (95% CI: 8.2\u201315.2). Infection\/cholangitis was the commonest AE, with a pooled incidence of 6.1% (95% CI: 3.7\u201310.1). The estimated incidence of stent dysfunction and reintervention was 10.5% (95% CI: 7.5\u201314.4), and 12.1% (95% CI: 9.3\u201315.7), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite with a high technical and clinical success rate, EUS\u2010CDS with LAMS may be associated with overall AEs and stent dysfunction in one\u2010fifth and one\u2010tenth of cases, respectively. Further efforts are required to optimize its safety and long\u2010term stent patency.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16614","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T04:45:51Z","timestamp":1715575551000},"page":"1769-1779","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Adverse events in endoscopic ultrasound\u2010guided choledochoduodenostomy with lumen\u2010apposing metal stents: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8805-5636","authenticated-orcid":false,"given":"Jia\u2010Su","family":"Li","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Changhai Hospital Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Tang","sequence":"additional","affiliation":[{"name":"Digestive 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