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In the majority of patients with NET, first\u2010line treatment is represented by somatostatin analogs (SSAs) that, despite being drugs with high tolerability (even at high doses) and providing to carcinoid symptoms control and anti\u2010proliferative effects, may present some side effects, with potential impact on quality of life and nutritional status. The most frequent side effects are represented by gastrointestinal events in particular alterations in bowel habits (diarrhea and constipation), abdominal pain, exocrine pancreatic insufficiency, and cholelithiasis. Considering the relative rarity of NETs, literature about frequency and standard clinical management of adverse events SSA\u2010related is still lacking and heterogeneous. The aim of this review is to arm gastroenterologists and other physicians treating NET patients with essential knowledge on the side effects of SSAs. By identifying and managing these adverse events early, healthcare professionals can offer optimal care, avert foreseeable complications, and ensure the best outcomes for patients. Without such early recognition, there is a risk of diminishing the patient's quality of life and their ability to sustain treatment over time.<\/jats:p>","DOI":"10.1111\/jgh.16638","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T04:44:08Z","timestamp":1716525848000},"page":"1737-1744","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Gastrointestinal side effects of somatostatin analogs in neuroendocrine tumors: a focused review"],"prefix":"10.1111","volume":"39","author":[{"given":"Matteo","family":"Marasco","sequence":"first","affiliation":[{"name":"Department of Medical\u2010Surgical Sciences and Translational Medicine, Sapienza University of Rome, Digestive Disease Unit ENETS Center of Excellence, Sant'Andrea University Hospital  Rome Italy"},{"name":"PhD in Translational Medicine and Oncology Sapienza University of Rome  Rome 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