{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:30:56Z","timestamp":1747186256961,"version":"3.40.5"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T00:00:00Z","timestamp":1717027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Primary biliary cholangitis (PBC) is an autoimmune\u2010mediated cholestatic liver disease that can progress to biliary cirrhosis and liver\u2010related death. The associations between baseline myostatin levels and clinical outcomes in PBC patients are unknown. We aimed to clarify the influence of myostatin levels on the clinical outcomes of PBC patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 119 PBC patients were analyzed in this study. Myostatin levels were measured in stored sera before ursodeoxycholic acid treatment, and their associations with the clinical features and prognosis of PBC patients were analyzed. We analyzed the correlation between serum myostatin and chemokines\/cytokines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum myostatin was significantly lower in PBC patients (2343\u00a0pg\/mL) than in healthy controls (4059\u00a0pg\/mL, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The prevalence of patients with low myostatin levels increased according to the severity of histological fibrosis. The serum myostatin concentration was negatively correlated with the IL\u20106 and leucine\u2010rich \u03b12 glycoprotein levels, but the chemokine concentration was not correlated with the myostatin concentration. Low myostatin in PBC patients was associated with shorter survival without liver\u2010related complications (hazard ratio [HR], 3.598; 95% confidence interval [CI], 1.27\u201310.1; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.015) and shorter transplant\u2010free survival (HR, 3.129; 95% CI, 1.02\u20139.56; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.045) independent of pretreatment GLOBE score. Patients with both high pretreatment GLOBE scores and low myostatin levels had poor prognoses (log\u2013rank test: <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A low serum myostatin concentration at diagnosis was associated with poor clinical outcomes. Assessment of circulating myostatin levels may improve the prediction of outcomes in patients with PBC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16639","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T03:45:25Z","timestamp":1717127125000},"page":"2069-2076","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A low baseline serum myostatin concentration is associated with poor clinical outcome in patients with primary biliary cholangitis"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2213-3918","authenticated-orcid":false,"given":"Manabu","family":"Hayashi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Fukushima Medical University  Fukushima 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