{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:30:46Z","timestamp":1787315446202,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>The development of acute pancreatitis (AP) is strongly linked to blood clotting and fibrinolysis issues. Modern clinical practices now utilize advanced blood markers like thrombin\u2013antithrombin III complex (TAT), plasmin\u2010\u03b12\u2010plasmin inhibitor complex, thrombomodulin (TM), and tissue plasminogen activator\u2013inhibitor complex (t\u2010PAIC) to assess thrombosis risk. Our study used a highly sensitive chemiluminescence technique to measure these markers in AP patients, aiming to determine their early predictive value for AP severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>There were 173 patients with AP, all of whom developed symptoms within 72\u00a0h; 102 individuals had onset symptoms within 48\u00a0h. The biomarkers were measured upon admission before determining the severity of AP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The levels of TAT, plasmin\u2010\u03b12\u2010plasmin inhibitor complex, TM, and t\u2010PAIC were significantly higher in the severe acute pancreatitis (SAP) group compared with the mild acute pancreatitis and moderate severe acute pancreatitis groups. For the patients within 72\u00a0h of onset, TAT, TM, and t\u2010PAIC predicted the occurrence of SAP. For the patients within 48\u00a0h of onset, TAT and t\u2010PAIC predicted the occurrence of SAP. The area under the curve (AUC) of prediction models is similar to Bedside Index for Severity in Acute Pancreatitis (BISAP) but significantly higher than C\u2010reactive protein (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Notably, t\u2010PAIC had a larger AUC than TAT, BISAP, and C\u2010reactive protein.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In the initial 48\u00a0h, plasma TAT and t\u2010PAIC levels may predict the development of SAP. Within 72\u00a0h, plasma levels of TAT, TM, and t\u2010PAIC may predict the development of SAP, and the TAT\u00a0+\u00a0TM\u00a0+\u00a0t\u2010PAIC prediction model achieved a maximum AUC of 0.915, comparable to BISAP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.16641","type":"journal-article","created":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T03:58:35Z","timestamp":1717214315000},"page":"2088-2096","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Predictive value of thrombin\u2013antithrombin III complex and tissue plasminogen activator\u2013inhibitor complex biomarkers in assessing the severity of early\u2010stage acute pancreatitis"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6735-2548","authenticated-orcid":false,"given":"Chushu","family":"Liao","sequence":"first","affiliation":[{"name":"Hematology Laboratory Hunan Provincial People's Hospital, 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