{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T07:25:06Z","timestamp":1778916306383,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:00:00Z","timestamp":1717977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Even with advancement of medical technologies, liver transplantation still faces several major challenges. Hence, other treatment modalities are urgently needed for patients with end\u2010stage liver disease. Stem cells from human exfoliated deciduous teeth (SHED) was discovered to have highly proliferative and pluripotent properties; including differentiation into hepatocyte\u2010like cells. This study aims to investigate the capability of intrasplenic transplanted SHED and SHED\u2010Hep cells in inducing proliferation of stem cells and native hepatocytes in order to accelerate liver regeneration in liver fibrosis mice models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>)\u2010injured male mice groups were used in this study. Two of those groups were transplanted with either SHED or SHED\u2010Hep, while the other did not undergo transplantation. One age\u2010 and sex\u2010 matched healthy mice group was used as control. All specimens were immunohistochemically stained with anti\u2010Ki\u201067 antibodies and anti\u2010proliferating cell nuclear antigen (PCNA) antibodies before counter stained with hematoxylin\u2013eosin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Anti\u2010Ki\u201067 antibodies staining: at both 8 and 12\u00a0weeks, proliferating activity was predominantly seen on both SHED\u2010 and SHED\u2010Hep\u2010transplanted CCl<jats:sub>4<\/jats:sub>\u2010injured mice groups, while control and non\u2010transplanted CCl<jats:sub>4<\/jats:sub>\u2010injured mice group showed little to no sign of proliferation activity. Anti\u2010PCNA staining: at both 8 and 12\u00a0weeks, significant proliferating activity was detected by PCNA staining, mainly on stem cells population area on SHED\u2010 and SHED\u2010Hep\u2010treated group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In conclusion, this study has provided the evidence that transplantation of SHED or SHED\u2010Hep on liver\u2010injured mice induced proliferation of both transplanted stem cells and native liver cells in order to accelerate liver regeneration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16651","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T06:42:45Z","timestamp":1718088165000},"page":"2190-2196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Potential role of stem cells from human exfoliated deciduous teeth in inducing liver 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