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However, the direction and magnitude between host microbiota and pancreas remains to be established. This study investigated the association between gut microbiota and acute pancreatitis using Mendelian randomization (MR) methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Summary statistics of gut microbiota abundance and acute pancreatitis were extracted from genome\u2010wide association studies (GWAS). The two\u2010sample bidirectional MR design was employed to assess genetic association between the microbiota and pancreatitis, followed by a comprehensive sensitivity analysis to verify the robustness of the results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven microbiota taxa have been identified as significantly associated with the development of pancreatitis. Host genetic\u2010driven order Bacteroidales and class Bacteroidia are associated with an increased risk of pancreatitis. The genera <jats:italic>Coprococcus<\/jats:italic> and <jats:styled-content style=\"fixed-case\"><jats:italic>Eubacterium fissicatena<\/jats:italic><\/jats:styled-content> group also exhibit a positive effect on the development of pancreatitis, while the genera <jats:italic>Prevotella<\/jats:italic>, <jats:italic>Ruminiclostridium<\/jats:italic>, and <jats:italic>Ruminococcaceae<\/jats:italic> act as protective factors against pancreatitis. In contrast, acute pancreatitis was positively correlated with phylum Proteobacteria and genus <jats:italic>Lachnospiraceae<\/jats:italic> and negatively correlated with genus <jats:italic>Holdemania<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The bidirectional relationship between gut microbiota and acute pancreatitis suggests a critical role for host\u2010microbiota crosstalk in the development of the disease. Targeted modulation of specific gut microbiota enables the prevention and treatment of acute pancreatitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16658","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T10:04:30Z","timestamp":1718705070000},"page":"1895-1902","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Association between gut microbiota and acute pancreatitis: a bidirectional Mendelian randomization study"],"prefix":"10.1111","volume":"39","author":[{"given":"Feng","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College Nanchang University  Nanchang Jiangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College Nanchang University  Nanchang Jiangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqing","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Affiliated Hospital of Jiujiang University  Jiujiang Jiangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanzhen","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Fengcheng People's Hospital  Fengcheng Jiangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College Nanchang University  Nanchang Jiangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4622-6040","authenticated-orcid":false,"given":"Xiaojiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College Nanchang University  Nanchang Jiangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0242-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(18)30211-5"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.20317"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2022.2068365"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111850"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/db21-0382"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-018-1529-0"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.988326"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.00776"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.17219"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyg070"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e7325"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n2233"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-020-00763-1"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05473-8"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15394"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2021.05.014"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv080"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.21965"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0099-7"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-020-0433-9"},{"key":"e_1_2_7_23_1","article-title":"Mendelian randomization","volume":"12","author":"Birney E","year":"2022","journal-title":"Cold Spring Harb. 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