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Due to its multifactorial features, the development of osteoporotic fracture involves a complex interplay of multiple risk factors, including genetic, environmental, and lifestyle factors. <jats:styled-content style=\"fixed-case\"><jats:italic>Helicobacter pylori<\/jats:italic><\/jats:styled-content>, which infects approximately 43% of the world's population, has been associated with increased fracture risk due to hypochlorhydria from atrophic gastritis and systemic inflammation from elevated pro\u2010inflammatory cytokines. However, the potential impact of <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u2009pylori<\/jats:italic><\/jats:styled-content> infection and eradication on fracture risk remains contentious among various studies due to the study design and inadequate adjustment of confounding factors including baseline gastritis phenotype. In this review, we provided a comprehensive evaluation of the current evidence focusing on the underlying mechanisms and clinical evidence of the association between <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u2009pylori<\/jats:italic><\/jats:styled-content> infection and osteoporotic fracture. We also discussed the potential benefits of <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u2009pylori<\/jats:italic><\/jats:styled-content> eradication on fracture risk.<\/jats:p>","DOI":"10.1111\/jgh.16664","type":"journal-article","created":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T06:59:10Z","timestamp":1719039550000},"page":"2006-2017","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Relationship between <scp><i>Helicobacter pylori<\/i><\/scp> infection, osteoporosis, and fracture"],"prefix":"10.1111","volume":"39","author":[{"given":"Jing Tong","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Medicine, School of Clinical Medicine The University of Hong Kong, Queen Mary Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching Lung","family":"Cheung","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacy, School of Clinical Medicine The University of Hong Kong, Queen Mary Hospital  Hong Kong China"},{"name":"Laboratory of Data Discovery for Health Limited (D24H)  Hong Kong Science Park Pak Shek Kok Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4838-378X","authenticated-orcid":false,"given":"Ka Shing","family":"Cheung","sequence":"additional","affiliation":[{"name":"Department of Medicine, School of Clinical Medicine The University of Hong Kong, Queen Mary Hospital  Hong Kong China"},{"name":"Department of Medicine The University of Hong Kong\u2010Shenzhen Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-021-02772-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4821"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glt092"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.5312\/wjo.v10.i3.166"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-016-0332-0"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2009.260"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9103253"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/127.5.990S"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa414"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2023.116755"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(23)00070-5"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91084-0"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0101852"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1963"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i4.563"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.9.1082"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13010278"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453679209154823"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453674.2012.717844"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20548"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4943(98)00110-1"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.141.11.7739"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.7.4858"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.778078"},{"key":"e_1_2_8_26_1","first-page":"6605","article-title":"TNF\u2010\u03b1 and RANKL promote osteoclastogenesis by upregulating RANK via the NF\u2010\u03baB pathway","volume":"17","author":"Luo G","year":"2018","journal-title":"Mol. 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