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CHB patients with low\u2010viral load but without consequent HBsAg loss were also enrolled at the ratio of 1:4. The factors contributing to HBsAg loss were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 80 patients were recruited for the current study, with a mean age of 63.9\u00a0years and 61.3% being male. Among them, 62.5% patients (50\/80) were treated with potent nucleoside\/nucleotide analogues (NAs) during the follow\u2010up period. Additionally, 12.5% patients (10\/80) had a prior history of NAs treatment before enrolment. During the follow\u2010up, HBsAg loss occurred in 17 patients (21.3%). Compared with patients without HBsAg loss, those with HBsAg loss were younger (57.9\u00a0years <jats:italic>vs<\/jats:italic> 65.5\u00a0years; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01), had lower HBV DNA levels (1.3 log<jats:sub>10<\/jats:sub> IU\/mL <jats:italic>vs<\/jats:italic> 2.3 log<jats:sub>10<\/jats:sub> IU\/mL; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003), and higher proportion of prior NAs\u2010treated history. Logistic regression analysis revealed that the factors associated with factors associated with HBsAg loss were age &lt;\u00a060\u00a0years (OR\/CI: 3.95\/1.15\u201313.60, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03), prior NAs\u2010treated history (OR\/CI: 7.59\/1.42\u201340.51, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01) and current NAs\u2010treated (OR\/CI: 0.19\/0.05\u20130.71, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the study, older age and prior NAs were positively associated with HBsAg loss, and current NAs was negatively associated with HBsAg loss. Additionally, some patients experienced HBsAg loss during the NAs therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16667","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T08:54:24Z","timestamp":1718960064000},"page":"2327-2331","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hepatitis B surface antigen loss in chronic hepatitis B patients with low\u2010viral\u2010load"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2961-130X","authenticated-orcid":false,"given":"Tyng\u2010Yuan","family":"Jang","sequence":"first","affiliation":[{"name":"PhD Program of Environmental and Occupational Medicine and Graduate Institute of Clinical Medicine Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Department of Internal Medicine Kaohsiung Medical University Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Department of Internal Medicine Pingtung Hospital, Ministry of Health and Welfare  Ping\u2010Tung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Batbold","family":"Batsaikhan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Institute of Medical Sciences Mongolian National University of Medical Sciences  Ulaanbaatar Mongolia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yo\u2010Chia","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biological Science and Technology National Pingtung University of Science and Technology  Pingtung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2296-3054","authenticated-orcid":false,"given":"Chia\u2010Yen","family":"Dai","sequence":"additional","affiliation":[{"name":"PhD Program of Environmental and Occupational Medicine and Graduate Institute of Clinical Medicine Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Department of Internal Medicine Kaohsiung Medical University Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"College of Professional Studies National Pingtung University of Science and Technology  Pingtung Taiwan"},{"name":"Drug Development and Value Creation Research Center Kaohsiung Medical University  Kaohsiung 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