{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T21:01:10Z","timestamp":1780606870075,"version":"3.54.1"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP2004495"],"award-info":[{"award-number":["APP2004495"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007615","name":"Centre of Excellence for Environmental Decisions, Australian Research Council","doi-asserted-by":"publisher","award":["APP170993"],"award-info":[{"award-number":["APP170993"]}],"id":[{"id":"10.13039\/100007615","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Patients with intestinal failure (IF) have abnormal intestinal anatomy, secretion, and dysmotility, which impairs intestinal homeostatic mechanisms and may lead to small intestinal bacterial overgrowth (SIBO). We conducted a systematic review and meta\u2010analysis to determine the prevalence of SIBO in patients with IF and to identify risk factors for SIBO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>MEDLINE (PubMed) and Embase electronic databases were searched from inception to December 2023 for studies that reported the prevalence of SIBO in IF. The prevalence rates, odds ratio (OR), and 95% confidence intervals of SIBO in IF and the risk factors for SIBO in IF were calculated using random effects model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Final dataset included nine studies reporting on 407 patients with IF. The prevalence of SIBO in IF was 57.5% (95% CI 44.6\u201369.4), with substantial heterogeneity in this analysis (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a080.9, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001). SIBO prevalence was sixfold higher in patients with IF who received parenteral nutrition (PN) compared with IF patients not on PN (OR\u00a0=\u00a06.0, 95% CI 3.0\u201311.9, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001). Overall, the prevalence of SIBO in patients with IF using PPI\/acid\u2010suppressing agents (72.0%, 95% CI 57.5\u201383.8) was numerically higher compared with IF patients not using these agents (47.6%, 95% CI 25.7\u201370.2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This systematic review and meta\u2010analysis suggests that there is an increased risk of SIBO in patients with IF and that PN, and potentially, the use of PPI\/acid\u2010suppressing agents is risk factors for SIBO development in patients with IF. However, the quality of evidence is low and can be attributed to lack of case\u2013control studies and clinical heterogeneity seen in the studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16668","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T11:00:41Z","timestamp":1719486041000},"page":"2308-2318","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prevalence of small intestinal bacterial overgrowth in intestinal failure syndrome: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"39","author":[{"given":"Ayesha","family":"Shah","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of Queensland  Brisbane Queensland Australia"},{"name":"Department of Gastroenterology and Hepatology Princess Alexandra Hospital  Brisbane Queensland Australia"},{"name":"Translational Research Institute  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Fairlie","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Queensland  Brisbane Queensland Australia"},{"name":"Department of Gastroenterology and Hepatology Princess Alexandra Hospital  Brisbane Queensland Australia"},{"name":"Translational Research Institute  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Morrison","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Queensland  Brisbane Queensland Australia"},{"name":"Department of Gastroenterology and Hepatology Princess Alexandra Hospital  Brisbane Queensland Australia"},{"name":"Faculty of Medicine, Frazer Institute University of Queensland  Woolloongabba Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal","family":"Martin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Queensland  Brisbane Queensland Australia"},{"name":"Department of Gastroenterology and Hepatology Princess Alexandra Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Hammer","sequence":"additional","affiliation":[{"name":"St. Anna Kinderspital Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann","family":"Hammer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Koloski","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Queensland  Brisbane Queensland Australia"},{"name":"Department of Gastroenterology and Hepatology Princess Alexandra Hospital  Brisbane Queensland Australia"},{"name":"Translational Research Institute  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Rezaie","sequence":"additional","affiliation":[{"name":"Karsh Division of Gastroenterology and Hepatology, Department of Medicine, Medically Associated Science and Technology (MAST) Program Cedars\u2010Sinai  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Pimentel","sequence":"additional","affiliation":[{"name":"Karsh Division of Gastroenterology and Hepatology, Department of Medicine, Medically Associated Science and Technology (MAST) Program Cedars\u2010Sinai  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purna","family":"Kashyap","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P","family":"Jones","sequence":"additional","affiliation":[{"name":"School of Psychological Sciences Macquarie University  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0206-2358","authenticated-orcid":false,"given":"Gerald","family":"Holtmann","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Queensland  Brisbane Queensland Australia"},{"name":"Department of Gastroenterology and Hepatology Princess Alexandra Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2021.07.002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2014.08.017"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ncp.10987"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200405000-00003"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.2003.tb08079.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11938-018-0207-x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12664-022-01292-x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-54843-4.00006-4"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03533.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-007-0065-1"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2023.06.001"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.1998.tb01122.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.12.008"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)80058-3"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781405195805.ch19"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13928"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12664-020-01107-x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/XEB.0000000000000054"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-5-13"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-135"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-015-0084-7"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.1316"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2012.03.019"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003501"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgh3.12174"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2005.10.020"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.1809"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000928"},{"key":"e_1_2_7_34_1","first-page":"1","article-title":"Asian\u2010Pacific consensus on small intestinal bacterial overgrowth in gastrointestinal disorders: an initiative of the Indian Neurogastroenterology and Motility Association","author":"Ghoshal UC","year":"2022","journal-title":"Indian J. Gastroenterol."},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000501"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-017-1371-9"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00768.x"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-021-06857-y"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000504"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.830356"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15920"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.1933313"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12456"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3181f44abc"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.16668","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T02:46:39Z","timestamp":1744253199000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.16668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,27]]},"references-count":43,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/jgh.16668"],"URL":"https:\/\/doi.org\/10.1111\/jgh.16668","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,27]]},"assertion":[{"value":"2024-03-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}