{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:36:09Z","timestamp":1789497369852,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100018540","name":"Science Fund for Distinguished Young Scholars of Guangdong Province","doi-asserted-by":"publisher","award":["2022B1515020024"],"award-info":[{"award-number":["2022B1515020024"]}],"id":[{"id":"10.13039\/501100018540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070574"],"award-info":[{"award-number":["82070574"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2018B030312009"],"award-info":[{"award-number":["2018B030312009"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2507500"],"award-info":[{"award-number":["2023YFC2507500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Liver stiffness measurements (LSMs) are promising for monitoring disease progression or regression. We assessed the prognostic significance of dynamic changes in LSM over time on liver\u2010related events (LREs) and death in patients with chronic hepatitis B (CHB) and compensated advanced chronic liver disease (cACLD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included 1272 patients with CHB and cACLD who underwent at least two measurements, including LSM and fibrosis score based on four factors (FIB\u20104). \u0394LSM was defined as [(follow\u2010up LSM\u00a0\u2212\u00a0baseline LSM)\/baseline LSM\u00a0\u00d7\u00a0100]. We recorded LREs and all\u2010cause mortality during a median follow\u2010up time of 46\u00a0months. Hazard ratios (HRs) and confidence intervals (CIs) for outcomes were calculated using Cox regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline FIB\u20104, baseline LSM, \u0394FIB\u20104, \u0394LSM, and \u0394LSM\/year were independently and simultaneously associated with LREs (adjusted HR, 1.04, 95% CI, 1.00\u20131.07; 1.02, 95% CI, 1.01\u20131.03; 1.06, 95% CI, 1.03\u20131.09; 1.96, 95% CI, 1.63\u20132.35, 1.02, 95% CI, 1.01\u20131.04, respectively). The baseline LSM combined with the \u0394LSM achieved the highest Harrell's C (0.751), integrated AUC (0.776), and time\u2010dependent AUC (0.737) for LREs. Using baseline LSM and \u0394LSM, we proposed a risk stratification method to improve clinical applications. The risk proposed stratification based on LSM performed well in terms of prognosis: low risk (<jats:italic>n<\/jats:italic>\u00a0=\u00a0390; reference), intermediate risk (<jats:italic>n<\/jats:italic>\u00a0=\u00a0446; HR\u00a0=\u00a03.38), high risk (<jats:italic>n<\/jats:italic>\u00a0=\u00a0272; HR\u00a0=\u00a05.64), and extremely high risk (<jats:italic>n<\/jats:italic>\u00a0=\u00a0164; HR\u00a0=\u00a011.11).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Baseline and repeated noninvasive tests measurement allow risk stratification of patients with CHB and cACLD. Combining baseline and dynamic changes in the LSM improves prognostic prediction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16673","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T07:55:48Z","timestamp":1719820548000},"page":"2169-2181","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Prognostic significance of dynamic changes in liver stiffness measurement in patients with chronic hepatitis B and compensated advanced chronic liver disease"],"prefix":"10.1111","volume":"39","author":[{"given":"Hongsheng","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology The Third Affiliated Hospital of Sun Yat\u2010Sen University  No. 600 Tianhe Road Guangzhou 510630 China"},{"name":"Guangdong Provincial Key Laboratory of Liver Disease Research  Guangzhou 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