{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:46:55Z","timestamp":1789501615300,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:00:00Z","timestamp":1721088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173318"],"award-info":[{"award-number":["82173318"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2024,11]]},"abstract":"Abstract<\/jats:title>\n \n Background and Aim<\/jats:title>\n \n \n Helicobacter pylori<\/jats:italic>\n <\/jats:styled-content>\n infection is linked to various gastrointestinal conditions, such as chronic active gastritis, peptic ulcers, and gastric cancer. Traditional treatment options encounter difficulties due to antibiotic resistance and adverse effects. Therefore, the aim of this study was to explore the effectiveness of a new treatment plan that combines vonoprazan (VPZ), amoxicillin, and bismuth for the eradication of\n \n H.\u2009pylori<\/jats:italic>\n <\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A total of 600 patients infected with\n \n H.\u2009pylori<\/jats:italic>\n <\/jats:styled-content>\n were recruited for this multicenter randomized controlled trial. Patients treated for\n \n H.\u2009pylori<\/jats:italic>\n <\/jats:styled-content>\n elimination were randomly assigned at a 1:1 ratio to receive 14\u00a0days of vonoprazan\u2010based triple therapy (vonoprazan + amoxicillin + bismuth, group A) or standard quadruple therapy (esomeprazole + clarithromycin + amoxicillin + bismuth, group B). Compliance and adverse effects were tracked through daily medication and side effect records. All patients underwent a 13C\/14C\u2010urea breath test 4\u00a0weeks after treatment completion.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Intention\u2010to\u2010treat (ITT) and per\u2010protocol (PP) analyses revealed no substantial differences in\n \n H.\u2009pylori<\/jats:italic>\n <\/jats:styled-content>\n eradication rates between groups A and B (ITT: 83.7%\n vs<\/jats:italic>\n 83.2%; PP: 90.9%\n vs<\/jats:italic>\n 89.7%). However, significant differences were observed in the assessment of side effects (13.7%\n vs<\/jats:italic>\n 28.6%,\n P<\/jats:italic>\n \u00a0<\u00a00.001). Specifically, group A had significantly fewer \u201cbitter mouths\u201d than group B did (3.7%\n vs<\/jats:italic>\n 16.2%,\n P<\/jats:italic>\n \u00a0<\u00a00.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Triple therapy comprising vonoprazan (20\u00a0mg), amoxicillin (750\u00a0mg), and bismuth potassium citrate (220\u00a0mg) achieved a PP eradication rate \u226590%, paralleling standard quadruple therapy, and had fewer adverse events and lower costs (\u00a5306.8\n vs<\/jats:italic>\n \u00a5645.8) for treatment\u2010naive patients.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgh.16679","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T20:43:16Z","timestamp":1721162596000},"page":"2293-2298","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Comparison of vonoprazan bismuth\u2010containing triple therapy with quadruple therapy in\n \n Helicobacter pylori<\/i>\n <\/scp>\n \u2010infected treatment\u2010naive patients: a prospective multicenter randomized controlled trial"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3441-7003","authenticated-orcid":false,"given":"Jing Wen","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye Gui","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Wuhan City Sixth Hospital Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Wuhan City Sixth Hospital Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi Yun","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hubei General Hospital Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Wang","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hubei General Hospital Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hubei General Hospital Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Wuhan City Third Hospital Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu Yu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Zhongshan Hospital of Hubei Province Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui Hong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Xiantao First People's Hospital Affiliated to Yangtze University Xiantao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui Zhen","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hongan People's Hospital Huanggang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian Guang","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Xianning Center Hospital Xianning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao Ming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Panzhihua Municipal Central Hospital Panzhihua China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"San Ping","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Wuhan Union Hospital of China Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li Ping","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Wuhan Asia Heart Hospital Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Hua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First People's Hospital of Tianmen City Tianmen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Chong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu Ya","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng Die","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan 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