{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T07:49:25Z","timestamp":1768895365316,"version":"3.49.0"},"reference-count":49,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T00:00:00Z","timestamp":1720569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["113\u2010S0040"],"award-info":[{"award-number":["113\u2010S0040"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Understanding the dynamics of serum Mac\u20102 binding protein glycosylation isomer (M2BPGi) remains pivotal for hepatitis C virus (HCV) patients' post\u2010sustained virologic response (SVR<jats:sub>12<\/jats:sub>) through direct\u2010acting antivirals (DAAs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We compared areas under receiver operating characteristic curves (AUROCs) of M2BPGi, FIB\u20104, and APRI and assess M2BPGi cutoff levels in predicting fibrosis stages of \u2265F3 and F4 utilizing transient elastography in 638 patients. Variations in M2BPGi levels from pretreatment to SVR<jats:sub>12<\/jats:sub> and their association with pretreatment alanine transaminase (ALT) levels and fibrosis stage were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The AUROCs of M2BPGi were comparable to FIB\u20104 in predicting \u2265F3 (0.914 <jats:italic>vs<\/jats:italic> 0.902, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.48) and F4 (0.947 <jats:italic>vs<\/jats:italic> 0.915, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.05) but were superior to APRI in predicting \u2265F3 (0.914 <jats:italic>vs<\/jats:italic> 0.851, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001) and F4 (0.947 <jats:italic>vs<\/jats:italic> 0.857, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Using M2BPGi cutoff values of 2.83 and 3.98, fibrosis stages of \u2265F3 and F4 were confirmed with a positive likelihood ratio \u226510. The median M2BPGi change was \u22120.55. Patients with ALT levels \u22655 times ULN or \u2265F3 demonstrated more pronounced median decreases in M2BPGi level compared to those with ALT levels 2\u20135 times ULN and &lt;2 times ULN (\u22120.97 <jats:italic>vs<\/jats:italic> \u22120.68 and \u22120.44; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) or with &lt; F3 (\u22121.52 <jats:italic>vs<\/jats:italic> \u22120.44; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum M2BPGi is a reliable marker for advanced hepatic fibrosis. Following viral clearance, there is a notable M2BPGi decrease, with the extent of reduction influenced by ALT levels and fibrosis stage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16680","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T01:54:35Z","timestamp":1720662875000},"page":"2439-2446","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Serum Mac\u20102 binding protein glycosylation isomer dynamics in patients achieving sustained virologic response for hepatitis C virus"],"prefix":"10.1111","volume":"39","author":[{"given":"Yu\u2010Ping","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital  Taipei 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