{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T01:56:03Z","timestamp":1788314163589,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Intraductal papillary mucinous neoplasm (IPMN)\u2010derived pancreatic ductal adenocarcinoma (PDAC) management is generally extrapolated from pancreatic intraepithelial neoplasia (PanIN)\u2010derived PDAC guidelines. However, these are biologically divergent, and heterogeneity further exists between tubular and colloid subtypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive upfront surgery patients with PanIN\u2010derived and IPMN\u2010derived PDAC were retrospectively identified from international centers (2000\u20132019). One\u2010to\u2010one propensity score matching for clinicopathologic factors generated three cohorts: IPMN\u2010derived versus PanIN\u2010derived PDAC, tubular IPMN\u2010derived versus PanIN\u2010derived PDAC, and tubular versus colloid IPMN\u2010derived PDAC. Overall survival (OS) was compared using Kaplan\u2013Meier and log\u2010rank tests. Multivariable Cox regression determined corresponding hazard ratios (HR) and 95% confidence intervals (95% CI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median OS (mOS) in 2350 PanIN\u2010derived and 700 IPMN\u2010derived PDAC patients was 23.0 and 43.1\u00a0months (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), respectively. PanIN\u2010derived PDAC had worse T\u2010stage, CA19\u20109, grade, and nodal status. Tubular subtype had worse T\u2010stage, CA19\u20109, grade, nodal status, and R1 margins, with a mOS of 33.7 versus 94.1\u00a0months (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) in colloid. Matched (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0495), PanIN\u2010derived and IPMN\u2010derived PDAC had mOSs of 30.6 and 42.8\u00a0months (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), respectively. In matched (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0341) PanIN\u2010derived and tubular IPMN\u2010derived PDAC, mOS remained poorer (27.7\n                      <jats:italic>vs<\/jats:italic>\n                      37.4,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Matched tubular and colloid cancers (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0112) had similar OS (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.55). On multivariable Cox regression, PanIN\u2010derived PDAC was associated with worse OS than IPMN\u2010derived (HR: 1.66, 95% CI: 1.44\u20131.90) and tubular IPMN\u2010derived (HR: 1.53, 95% CI: 1.32\u20131.77) PDAC. Colloid and tubular subtype was not associated with OS (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.16).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PanIN\u2010derived PDAC has worse survival than IPMN\u2010derived PDAC supporting distinct outcomes. Although more indolent, colloid IPMN\u2010derived PDAC has similar survival to tubular after risk adjustment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.16686","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T01:16:36Z","timestamp":1722474996000},"page":"2360-2366","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Outcomes in intraductal papillary mucinous neoplasm\u2010derived pancreatic cancer differ from PanIN\u2010derived pancreatic cancer"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3445-2278","authenticated-orcid":false,"given":"Joseph R.","family":"Habib","sequence":"first","affiliation":[{"name":"Department of Surgery New York University Langone Health  New York New York USA"},{"name":"Department of Surgery Regional Academic Cancer Center Utrecht, UMC Utrecht Cancer Center and St. Antonius Hospital Nieuwegein  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingmar F.","family":"Rompen","sequence":"additional","affiliation":[{"name":"Department of Surgery New York University Langone Health  New York New York USA"},{"name":"Heidelberg University Hospital  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ammar A.","family":"Javed","sequence":"additional","affiliation":[{"name":"Department of Surgery New York University Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahip","family":"Grewal","sequence":"additional","affiliation":[{"name":"Department of Surgery New York University Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedict","family":"Kinny\u2010K\u00f6ster","sequence":"additional","affiliation":[{"name":"Heidelberg University Hospital  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul C.M.","family":"Andel","sequence":"additional","affiliation":[{"name":"Department of Surgery Regional Academic Cancer Center Utrecht, UMC Utrecht Cancer Center and St. Antonius Hospital Nieuwegein  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Brock","family":"Hewitt","sequence":"additional","affiliation":[{"name":"Department of Surgery New York University Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg D.","family":"Sacks","sequence":"additional","affiliation":[{"name":"Department of Surgery New York University Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc G.","family":"Besselink","sequence":"additional","affiliation":[{"name":"Department of Surgery Amsterdam UMC, location University of Amsterdam  Amsterdam The Netherlands"},{"name":"Cancer Center Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hjalmar C.","family":"van Santvoort","sequence":"additional","affiliation":[{"name":"Department of Surgery Regional Academic Cancer Center Utrecht, UMC Utrecht Cancer Center and St. Antonius Hospital Nieuwegein  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lois A.","family":"Daamen","sequence":"additional","affiliation":[{"name":"Department of Surgery Regional Academic Cancer Center Utrecht, UMC Utrecht Cancer Center and St. Antonius Hospital Nieuwegein  Utrecht The Netherlands"},{"name":"Division of Imaging and Oncology University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Loos","sequence":"additional","affiliation":[{"name":"Heidelberg University Hospital  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"He","sequence":"additional","affiliation":[{"name":"Department of Surgery Johns Hopkins Hospital  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus W.","family":"B\u00fcchler","sequence":"additional","affiliation":[{"name":"Champalimaud Foundation  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L.","family":"Wolfgang","sequence":"additional","affiliation":[{"name":"Department of Surgery New York University Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. Quintus","family":"Molenaar","sequence":"additional","affiliation":[{"name":"Department of Surgery Regional Academic Cancer Center Utrecht, UMC Utrecht Cancer Center and St. Antonius Hospital Nieuwegein  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,31]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.688377"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2018.10.004"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-018-6425-6"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2019.09.014"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3639-0"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31819a6e16"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ctg.2017.3"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.19.21824"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/20584601231157046"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000813"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2018.09.013"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-022-05428-4"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.232272"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr561"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21388"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwj149"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.2307\/2533160"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2011.04.003"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15041185"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2021.06.006"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e318215010c"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2021.12.009"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318214bcb4"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2021.07.009"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181cf8a19"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001319"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005313"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2016.08.011"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2019.10.37"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.16686","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T22:46:45Z","timestamp":1744238805000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.16686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,31]]},"references-count":29,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/jgh.16686"],"URL":"https:\/\/doi.org\/10.1111\/jgh.16686","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,31]]},"assertion":[{"value":"2024-03-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}