{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T09:33:42Z","timestamp":1746524022612,"version":"3.40.4"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T00:00:00Z","timestamp":1724112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600417"],"award-info":[{"award-number":["81600417"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20211384"],"award-info":[{"award-number":["BK20211384"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Vitamin D (VD) deficiency was reported to correlate with ulcerative colitis (UC) activity, which might be closely related to gut microbiota dysbiosis. This study aims to investigate the effects of washed microbiota transplantation (WMT) on VD metabolism in UC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The serum levels of 25\u2010hdroxyvitamin D [25(OH)D] in 121 patients with UC and 53 healthy controls (HC) were detected. Subsequently, a non\u2010randomized control trial (non\u2010RCT) was conducted. Patients with UC were non\u2010randomly assigned to undergo WMT (<jats:italic>n<\/jats:italic>\u00a0=\u00a028) <jats:italic>vs<\/jats:italic>. conventional treatment (5\u2010aminosalicylic acid, 5\u2010ASA, <jats:italic>n<\/jats:italic>\u00a0=\u00a010). Serum levels of 25(OH)D, fecal microbiota, and the expression of vitamin D receptor (VDR) in patients with UC were evaluated with a 3\u2010month follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum VD levels collected in the clinic practice indicated that patients with UC had significantly lower VD levels than HC (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). In the non\u2010RCT, serum 25(OH)D level and VDR expression significantly increased (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.011, 0.026, respectively) in the WMT group, while no noticeable changes were observed in the non\u2010WMT group. Microbiome profiling revealed that the increase in VD levels after WMT was positively associated with the abundances of <jats:italic>Adlercreutzia_equolifaciens<\/jats:italic>, <jats:italic>Ruminococcus_obeum<\/jats:italic>, and <jats:italic>Dorea<\/jats:italic> but negatively correlated with <jats:italic>Escherichia<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The study suggested that WMT increases the levels of VD with characteristic changes of specific microbiota, which indicated the association between the VD and the activity of UC might be regulated by gut microbiota.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16717","type":"journal-article","created":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T10:54:21Z","timestamp":1724151261000},"page":"2394-2401","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Washed microbiota transplantation improved the level of serum vitamin D in ulcerative colitis"],"prefix":"10.1111","volume":"39","author":[{"given":"Hui","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Nutrition The Second Affiliated Hospital of Nanjing Medical University  Nanjing China"},{"name":"Department of Microbiota Medicine and Medical Center for Digestive Diseases The Second Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyan","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Microbiota Medicine and Medical Center for Digestive Diseases The Second Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quan","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Microbiota Medicine and Medical Center for Digestive Diseases The Second Affiliated Hospital of Nanjing Medical University  Nanjing 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