{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:23:32Z","timestamp":1789676612030,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>\n                      This study aimed to compare the determinants and impact of hepatocellular carcinoma (HCC) surveillance rates for people with metabolic dysfunction\u2010associated steatotic liver disease (MASLD)\n                      <jats:italic>versus<\/jats:italic>\n                      other chronic liver diseases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A dataset of HCC patients from a UK hospital (2007\u20132022) was analyzed. The Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      \u2010test compared continuous variables. The\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      and two\u2010tailed Fisher exact tests compared categorical data. Regression modeling analyzed the impact of MASLD on the size and number of HCC nodules and curative treatment. The Cox proportional hazards model assessed the influence of MASLD on overall survival.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 176 of 687 (25.6%) HCC patients had MASLD. Fewer people with MASLD HCC were enrolled in HCC surveillance compared to non\u2010MASLD HCC (38 [21.6%]\n                      <jats:italic>vs<\/jats:italic>\n                      215 [42.1%],\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Patients with MASLD HCC were less likely to have been under secondary care (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a057 [32.4%]\n                      <jats:italic>vs<\/jats:italic>\n                      259 [50.7%],\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and less likely to have cirrhosis (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0113 [64.2%]\n                      <jats:italic>vs<\/jats:italic>\n                      417 [81.6%],\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). MASLD was associated with a 12.3\u2010mm (95% confidence interval [CI] 10.8\u201314.0\u00a0mm) greater tumor diameter compared to people without MASLD (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.002). Patients with MASLD HCC had 0.62 reduced odds (95% CI 0.43\u20130.91) of receiving curative treatment compared to non\u2010MASLD HCC (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.014). Overall survival was similar for patients with MASLD HCC\n                      <jats:italic>versus<\/jats:italic>\n                      non\u2010MASLD HCC (hazard ratio 1.03, 95% CI 0.85\u20131.25,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.748).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with MASLD are less likely to have been enrolled in HCC surveillance due to undiagnosed cirrhosis or presenting with non\u2010cirrhotic HCC. Patients with MASLD HCC present with larger tumors and are less likely to receive curative treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.16727","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T20:15:04Z","timestamp":1724789704000},"page":"2817-2825","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Lower hepatocellular carcinoma surveillance in metabolic dysfunction\u2010associated steatotic liver disease: Impact on treatment eligibility"],"prefix":"10.1111","volume":"39","author":[{"given":"Connor","family":"Henry\u2010Blake","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Liverpool University Hospitals NHS Foundation Trust  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay","family":"Balachandrakumar","sequence":"additional","affiliation":[{"name":"Department of 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