{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:27:29Z","timestamp":1792189649499,"version":"4.4.0"},"reference-count":57,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Alcohol\u2010associated liver disease (ALD), including alcoholic fatty liver, is a serious problem in many countries, and its economic costs to society are enormous. There is evidence indicating the relations between gut environments and liver disease, and thus, improvement of gut environment is expected to be an effective approach for ALD prevention. In this study, we explored the preventive effect of partially hydrolyzed guar gum (PHGG) on ALD focusing on the gut\u2013liver axis. Two weeks of PHGG pre\u2010feeding suppressed the liver fat accumulation in the experimental binge alcohol model mouse. In cecal microbiome, PHGG pre\u2010feeding increased beneficial\n                    <jats:italic>Bifidobacterium<\/jats:italic>\n                    with its metabolite acetate concentration and suppressed the alcohol\u2010induced increase in the potential pathobiont\n                    <jats:italic>Streptococcus<\/jats:italic>\n                    . PHGG pre\u2010feeding increased colonic gene expression of angiogenin genes, which act as antimicrobial peptides and decreased expression of genes for mast cell protease, which suggests a potential involvement in leaky gut. Correlation network analysis based on evaluated parameters revealed four relations worth noticing. (i) The abundance of\n                    <jats:italic>Bifidobacterium<\/jats:italic>\n                    positively correlated with cecal acetate. (ii) Cecal acetate negatively correlated with\n                    <jats:italic>Streptococcus<\/jats:italic>\n                    via colonic angiogenin expression. (iii)\n                    <jats:italic>Streptococcus<\/jats:italic>\n                    positively correlated with liver fat area. (iv) Cecal acetate had direct negative correlation with liver fat area. Considering these relations comprehensively, acetate produced by\n                    <jats:italic>Bifidobacterium<\/jats:italic>\n                    may be a key mediator in ALD prevention; it inhibited growth of potential pathobiont\n                    <jats:italic>Streptococcus<\/jats:italic>\n                    and also directly regulated liver lipid metabolism reaching through portal vein. This study demonstrated that regularly intake of PHGG may be effective in reducing the risk of alcoholic fatty liver via gut\u2013liver axis.\n                  <\/jats:p>","DOI":"10.1111\/jgh.16737","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T21:29:52Z","timestamp":1727126992000},"page":"2700-2708","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Partially hydrolyzed guar gum suppresses binge alcohol\u2010induced liver fat accumulation via gut environment modulation in mice"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1792-1658","authenticated-orcid":false,"given":"So","family":"Morishima","sequence":"first","affiliation":[{"name":"Laboratory of Food Function, Department of Life Sciences, Graduate School of Bioresources Mie University  Tsu Mie Japan"},{"name":"Nutrition Division Taiyo Kagaku Co. 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