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We conducted a comprehensive literature review of English\u2010language original research articles published from 1990 to 2023, sourced from PubMed, Embase, and Web of Science, aiming to collate studies that provided a comparative analysis of physiological, metabolic, and hepatic histological characteristics between MASLD models and control groups. The establishment of a robust metabolic dysfunction\u2010associated steatotic liver rodent model hinges on various factors, including animal species and strains, sex, induction agents and methodologies, and the duration of induction. Through this review, we aim to guide researchers in selecting suitable induction methods and animal species for constructing preclinical models aligned with their specific research objectives and laboratory conditions. Future studies should strive to develop simple, reliable, and reproducible models, considering the model's sensitivity to factors such as light\u2013dark cycles, housing conditions, and environmental temperature. Additionally, the potential of diverse in vitro models, including 3D models and liver organ technology, warrants further exploration as valuable tools for unraveling the cellular mechanisms underlying fatty liver disease.<\/jats:p>","DOI":"10.1111\/jgh.16749","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T19:39:06Z","timestamp":1727293146000},"page":"48-66","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Rodent model of metabolic dysfunction\u2010associated fatty liver disease: a systematic review"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1347-5009","authenticated-orcid":false,"given":"Xiao\u2010Shan","family":"Cui","sequence":"first","affiliation":[{"name":"Institute of Basic Medical Sciences, Xiyuan Hospital China Academy of Chinese Medical Sciences  Beijing 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