{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T17:07:19Z","timestamp":1789664839615,"version":"4.0.1"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T00:00:00Z","timestamp":1728950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T00:00:00Z","timestamp":1728950400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81202882"],"award-info":[{"award-number":["81202882"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Kui\u2010Jie\u2010Ling capsule (Kui\u2010Jie\u2010Ling) is a hospital preparation for ulcerative colitis (UC) in China. This study aimed at evaluating the protective effects and mechanisms of Kui\u2010Jie\u2010Ling and Kui\u2010Jie\u2010Ling combined with adalimumab on UC induced by dextran sulfate sodium (DSS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Network pharmacology was combined with an animal experiment to reveal the targets of Kui\u2010Jie\u2010Ling alleviating UC. The UC model was established by drinking 2.5% DSS solution for 7\u00a0days. On the second day, the mice in the Kui\u2010Jie\u2010Ling group were orally administered with Kui\u2010Jie\u2010Ling (1.5 and 3.0\u00a0g\/kg) daily for seven consecutive days, and the mice in the combination group were orally administered with Kui\u2010Jie\u2010Ling (3.0\u00a0g\/kg) once a day for seven consecutive days and received one subcutaneous injection of adalimumab. The disease activity index, the colon length, the spleen index, the cytokines, the colon, the short\u2010chain fatty acid content, and the gut microbiota in the colon were analyzed. The role of gut microbiota against UC was verified by fecal microbiota transplantation experiments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The animal study's results were consistent with the network pharmacology analysis, which reflected that Kui\u2010Jie\u2010Ling alleviated UC via multi\u2010pathway. Kui\u2010Jie\u2010Ling ameliorated UC by inhibiting the formation of neutrophil extracellular traps (NETs), regulating inflammatory factors through the lipopolysaccharide\u2013toll\u2010like receptor 4\/nuclear factor kappa B and interleukin\u201023\u2013Janus kinase 2\/signal transducer and activator of transcription 3 signaling pathway, and restoring intestinal homeostasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These studies provided the experimental basis for the clinical administration of Kui\u2010Jie\u2010Ling and Kui\u2010Jie\u2010Ling combined with adalimumab against UC.<\/jats:p>\n                  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