{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:00:08Z","timestamp":1773000008640,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Acute pancreatitis (AP) is a complex disease most commonly caused by gallstones, alcohol intake, or hypertriglyceridemia. Even in subjects with hypertriglyceridemia, the risk of AP is heterogeneous. Identifying individuals with a high genetic susceptibility to AP could contribute to a better risk stratification in the clinic. This study aimed to determine if a weighted polygenic risk score (PRS) of common variants in pancreatitis susceptibility genes can independently predict all\u2010cause AP incidence in the general population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A weighted PRS was calculated for 484\u00a0932 individuals from the UK Biobank, including 3346 individuals who developed AP during follow\u2010up. The PRS included eight single nucleotide polymorphisms in known pancreatitis susceptibility genes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Individuals with a pancreatitis PRS above the 90th percentile had a 1.21\u2010fold (1.03\u20131.43;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.02) increased risk of AP compared with those with a pancreatitis PRS below the 90th percentile. When comparing individuals in the third tertile\n                      <jats:italic>versus<\/jats:italic>\n                      the first tertile, the risk of AP was 1.13\u2010fold (1.00\u20131.28;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.06) higher. Individuals with both a high triglyceride (TG) level and a high pancreatitis PRS (third tertile) had a 2.31\u2010fold (1.83\u20132.93;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a03.4\u00a0\u00d7\u00a010\n                      <jats:sup>\u221212<\/jats:sup>\n                      ) increased risk of AP compared with those with a low pancreatitis PRS and a low TG level (first tertile). Overall, the association between pancreatitis PRS and incident AP was independent of baseline TG level.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Results of this study suggest that the accumulation of common variants in pancreatitis susceptibility genes is associated with all\u2010cause AP incidence. Pancreatitis PRS could help clinicians identify patients who may be at higher risk of AP and who may benefit from more aggressive treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.16759","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T08:23:59Z","timestamp":1728548639000},"page":"2639-2644","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pancreatitis polygenic risk score is independently associated with all\u2010cause acute pancreatitis risk in the UK Biobank"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6327-7048","authenticated-orcid":false,"given":"Simon\u2010Pierre","family":"Guay","sequence":"first","affiliation":[{"name":"Genetic Dyslipidemia Clinic Montreal Clinical Research Institute  Montreal Quebec Canada"},{"name":"Division of Endocrinology, Department of Medicine Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"},{"name":"Division of Medical Genetics, Department of Pediatrics Universit\u00e9 de Sherbrooke  Sherbrooke Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eloi","family":"Gagnon","sequence":"additional","affiliation":[{"name":"Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec\u2010Universit\u00e9 Laval  Qu\u00e9bec Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7555-1275","authenticated-orcid":false,"given":"Martine","family":"Paquette","sequence":"additional","affiliation":[{"name":"Genetic Dyslipidemia Clinic Montreal Clinical Research Institute  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9bastien","family":"Th\u00e9riault","sequence":"additional","affiliation":[{"name":"Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec\u2010Universit\u00e9 Laval  Qu\u00e9bec Quebec Canada"},{"name":"Department of Molecular Biology, Medical Biochemistry and Pathology, Faculty of Medicine Universit\u00e9 Laval  Qu\u00e9bec Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benoit J","family":"Arsenault","sequence":"additional","affiliation":[{"name":"Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec\u2010Universit\u00e9 Laval  Qu\u00e9bec Quebec Canada"},{"name":"Department of Medicine, Faculty of Medicine Universit\u00e9 Laval  Qu\u00e9bec Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis","family":"Baass","sequence":"additional","affiliation":[{"name":"Genetic Dyslipidemia Clinic Montreal Clinical Research Institute  Montreal Quebec Canada"},{"name":"Division of Experimental Medicine and Medical Biochemistry, Department of Medicine McGill University  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v29.i18.2747"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v29.i7.1194"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2022.05.064"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-74943-8"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0000000000000866"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2466"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314454"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000461"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.01.028"},{"key":"e_1_2_8_11_1","article-title":"Pancreatitis polygenic risk score is associated with acute pancreatitis in multifactorial chylomicronemia syndrome","volume":"1933","author":"Guay SP","year":"2024","journal-title":"J. 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