{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T06:12:52Z","timestamp":1778739172732,"version":"3.51.4"},"reference-count":75,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:00:00Z","timestamp":1728604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:00:00Z","timestamp":1728604800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>This study aimed to investigate the relationship between advanced lung cancer inflammation index (ALI) and non\u2010alcoholic fatty liver disease (NAFLD) and advanced liver fibrosis (AF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 5642 individuals from the National Health and Nutrition Examination Survey (NHANES) between 2017 and 2020 were examined. Limited cubic spline regression model, and weighted logistic regression were employed to determine if ALI levels were related to the prevalence of NAFLD and AF. Additionally, a mediating analysis was conducted to investigate the role of lipid biomarkers, such as total cholesterol (TC) and high\u2010density lipoprotein cholesterol (HDL\u2010C), in the effects of ALI on the prevalence of NAFLD and AF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After adjusting for potential confounders, a significant positive association was found between ALI with NAFLD and AF prevalence. Compared with those in ALI Tertile 1, participants in Tertile 3 had higher odds of NAFLD prevalence (odds ratio [OR]: 3.16; 95% confidence interval [CI]: 2.52\u20133.97) and AF (OR: 3.17; 95% CI: 2.30\u20134.36). Participants in both Tertile 2 and Tertile 3 had lower odds of developing AF (\n                      <jats:italic>P<\/jats:italic>\n                      for trend\u00a0=\u00a00.005). Moreover, we discovered a nonlinear association between ALI and NAFLD. An inflection point of 74.25 for NAFLD was identified through a two\u2010segment linear regression model. Moreover, TC and HDL\u2010C levels mediated the association between ALI and NAFLD by 10.2% and 4.2%, respectively (both\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that higher ALI levels are positively associated with an increased prevalence of NAFLD and AF, partly mediated by lipid biomarkers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.16760","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T06:54:32Z","timestamp":1728629672000},"page":"2853-2862","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Relevance of combined influence of nutritional and inflammatory status on non\u2010alcoholic fatty liver disease and advanced fibrosis: A mediation analysis of lipid biomarkers"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3779-3357","authenticated-orcid":false,"given":"Lei","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Histology and embryology Hebei Medical University  Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Histology and embryology Hebei Medical University  Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huijuan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of physiology Hebei Medical University  Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Ding","sequence":"additional","affiliation":[{"name":"Hubei Jingmen Maternal and Child Health Hospital  Jingmen 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