{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T01:25:52Z","timestamp":1787966752009,"version":"build-2784847793"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,11,24]],"date-time":"2024-11-24T00:00:00Z","timestamp":1732406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,11,24]],"date-time":"2024-11-24T00:00:00Z","timestamp":1732406400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2022J01121025"],"award-info":[{"award-number":["2022J01121025"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>\n                      Only a few studies have investigated the efficacy and safety of different durations of vonoprazan and amoxicillin (VA) high\u2010dose dual therapy for the eradication of\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">Helicobacter pylori<\/jats:styled-content>\n                      <\/jats:italic>\n                      . We aimed to compare the efficacy and safety of 10\u00a0days\n                      <jats:italic>versus<\/jats:italic>\n                      14\u00a0days of VA high\u2010dose dual therapy for\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H.\u00a0pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      eradication.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study was conducted in 14 centers in China. A total of 250 patients infected with\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H.\u00a0pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      were randomly assigned to Group VA\u201010 or VA\u201014. Both groups received the VA dual therapy (vonoprazan 20\u00a0mg twice daily\u00a0+\u00a0amoxicillin 1000\u00a0mg three times daily). The primary endpoint was the\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H.\u00a0pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      eradication rate. Secondary endpoints included adverse events and patient compliance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Group VA\u201010 achieved eradication rates of 89.60%, 91.06%, and 91.67% as determined by the intention\u2010to\u2010treat (ITT), modified intention\u2010to\u2010treat (MITT), and per\u2010protocol (PP) analysis, respectively. The eradication rates were similar to those in Group VA\u201014: 91.20%, 93.44%, and 93.39%. The difference and 90% confidence interval boundary \u22121.60% (\u22127.73% to 4.53%) in the ITT analysis, \u22122.39% (\u22128.00% to 3.23%) in the MITT analysis, and \u22121.72% (\u22127.29% to 3.85%) in the PP analysis were greater than the predefined noninferiority margin of \u221210%, establishing a noninferiority of Group VA\u201010\n                      <jats:italic>versus<\/jats:italic>\n                      Group VA\u201014 (noninferiority\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.001 in ITT analysis,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001 in MITT analysis, and\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001 in PP analysis, respectively). No significant differences were observed in adverse events between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Ten\u2010day VA dual therapy achieves comparable efficacy and safety to the 14\u2010day regimen in Chinese population, providing patients with greater convenience and economic benefits.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.16761","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T01:39:54Z","timestamp":1732498794000},"page":"2645-2653","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Ten\u2010day\n                    <i>versus<\/i>\n                    14\u2010day vonoprazan\u2010amoxicillin high\u2010dose dual therapy for\n                    <i>Helicobacter pylori<\/i>\n                    eradication in China: A multicenter, open\u2010label, randomized study"],"prefix":"10.1111","volume":"39","author":[{"given":"Aiping","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Shengli Clinical Medical College of Fujian Medical University  Fuzhou China"},{"name":"Department of Gastroenterology Fujian Provincial Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shengli Clinical Medical College of Fujian Medical University  Fuzhou China"},{"name":"Department of Gastroenterology Fujian Provincial Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Fujian Medical University  Fuzhou 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