{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:07:08Z","timestamp":1791648428993,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,3]],"date-time":"2024-11-03T00:00:00Z","timestamp":1730592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,11,3]],"date-time":"2024-11-03T00:00:00Z","timestamp":1730592000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>\n                      Tofacitinib and\n                      <jats:bold>aminosalicylic<\/jats:bold>\n                      acid (5\u2010ASA) are commonly used to treat ulcerative colitis (UC). However, evidence on the effect of concomitant 5\u2010ASA use in patients receiving tofacitinib is limited. This study investigated the effects of 5\u2010ASA combined with tofacitinib in UC patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study used data from the Medical Data Vision database, including patients with UC treated with tofacitinib from May 2018 to April 2022. Patients were grouped according to tofacitinib dosage and assessed for the efficacy of concomitant 5\u2010ASA use. The primary endpoint was clinical relapse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1213 patients with UC were included in the analysis, with 416 in the 5\u00a0mg BID group and 797 in the 10\u00a0mg BID group. In the 5\u00a0mg BID group, the cumulative relapse\u2010free rate was significantly higher in patients receiving concomitant 5\u2010ASA (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001). Multivariate Cox regression analysis confirmed that concomitant 5\u2010ASA use significantly reduced the risk of clinical relapse (adjusted hazard ratio [HR], 0.47; 95% confidence interval [CI], 0.31\u20130.70). In the 10\u00a0mg BID group, no significant difference was noted in the cumulative relapse\u2010free rate between patients treated with and without 5\u2010ASA (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.445). Similarly, multivariate Cox regression analysis indicated that concomitant 5\u2010ASA use did not significantly affect relapse risk (adjusted HR, 0.97; 95% CI, 0.71\u20131.32).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Concomitant 5\u2010ASA use reduced the risk of relapse in patients on 5\u00a0mg tofacitinib BID, suggesting benefits at lower doses. However, no significant benefit was observed with 5\u2010ASA use in those 10\u00a0mg tofacitinib BID.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.16786","type":"journal-article","created":{"date-parts":[[2024,11,3]],"date-time":"2024-11-03T21:28:36Z","timestamp":1730669316000},"page":"108-114","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Evaluating the effects of 5\u2010aminosalicylic acid on tofacitinib treatment in ulcerative colitis"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3369-5059","authenticated-orcid":false,"given":"Yu","family":"Nishida","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine Osaka Metropolitan University  Osaka 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