{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:03:21Z","timestamp":1791407001107,"version":"4.3.3"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Gel immersion (GI) endoscopy provides a good visual field in endoscopic submucosal dissection (ESD); however, its clinical outcomes are poorly understood. This study aimed to compare the treatment outcomes between esophageal gel immersion endoscopic submucosal dissection (GI\u2010ESD) and conventional ESD (C\u2010ESD) to determine the safety and efficacy of GI\u2010ESD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The data of 71 consecutive patients who underwent esophageal ESD between April 2021 and March 2023 at a Japanese tertiary center were retrospectively reviewed. GI was achieved using an additional irrigation tube. The treatment outcomes between the GI\u2010ESD and C\u2010ESD groups were compared using inverse probability of treatment weighting (IPTW) to control for confounding factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 75 superficial esophageal epithelial neoplasms (41 in the C\u2010ESD and 34 in the GI\u2010ESD groups) were treated using ESD. The mean procedure time in the GI\u2010ESD group was significantly shorter than that in the C\u2010ESD group (59.2\u00a0\u00b1\u00a036.2\n                      <jats:italic>vs<\/jats:italic>\n                      85.3\u00a0\u00b1\u00a045.7\u00a0min,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.008). After IPTW adjustment, the mean procedural times were 62.6\u00a0\u00b1\u00a036.6 and 82.9\u00a0\u00b1\u00a041.7\u00a0min in the GI\u2010ESD and C\u2010ESD groups, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.037), and the incidence rate of muscle layer damage was 4.2% in the GI\u2010ESD group and 30.6% in the C\u2010ESD group (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.001). In the multivariate analysis, specimen size \u2265\u00a030\u00a0mm (odds ratio [OR]: 9.44, 95% confidence interval [CI]: 2.46\u201336.30,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.001) was positively correlated with longer procedural time (\u2265\u00a090\u00a0min), whereas GI\u2010ESD (OR: 0.19, 95%CI: 0.05\u20130.68,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.011) showed a negative association.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Esophageal GI\u2010ESD may be useful in terms of safety and time efficiency. The GI technique could be an option for esophageal ESD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.16800","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T21:05:59Z","timestamp":1730754359000},"page":"218-225","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Safety and efficacy of endoscopic submucosal dissection with gel immersion technique for superficial esophageal neoplasms"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7721-8292","authenticated-orcid":false,"given":"Taro","family":"Iwatsubo","sequence":"first","affiliation":[{"name":"Second Department of Internal Medicine Osaka Medical and Pharmaceutical University  Osaka Japan"},{"name":"Endoscopy Center Osaka Medical and Pharmaceutical University Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akitoshi","family":"Hakoda","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine Osaka Medical and Pharmaceutical University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Sugawara","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine Osaka Medical and Pharmaceutical University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine Osaka Medical and Pharmaceutical University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine Osaka Medical and Pharmaceutical University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Mori","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine Osaka Medical and Pharmaceutical University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironori","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine Osaka Medical and Pharmaceutical University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Ota","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine Osaka Medical and Pharmaceutical University  Osaka Japan"},{"name":"Endoscopy Center Osaka Medical and Pharmaceutical University Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihisa","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine Osaka Medical and Pharmaceutical University  Osaka Japan"},{"name":"Endoscopy Center Osaka Medical and Pharmaceutical University Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine Osaka Medical and Pharmaceutical University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1391844"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(05)00291-0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.03.024"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i18.5540"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-018-6591-4"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10388-022-00913-w"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-020-07777-0"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10388-022-00974-x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2019.08.014"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2022.04.016"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/doz077"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2017.11.032"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-018-6278-x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2015.09.048"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1400-8289"},{"key":"e_1_2_7_17_1","first-page":"247","article-title":"A novel gel immersion technique using a bipolar needle\u2010knife in endoscopic submucosal dissection for superficial gastrointestinal neoplasms","volume":"31","author":"Akasaka T","year":"2018","journal-title":"Ann. 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