{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T19:37:02Z","timestamp":1771961822413,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>We conducted a retrospective study to identify incidence rates and potential risk factors of major adverse cardiac events (MACE) in Japanese patients with ulcerative colitis (UC), as existing data are scarce, inconsistent, and provide limited representation of the real\u2010world situation of MACE in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We utilized administrative claims data, collected between January 2013 and December 2022, from Medical Data Vision, Japan. Patients (aged \u2265\u200920\u2009years) diagnosed with UC within \u00b1\u20091\u2009month of the prescription date during the study period were included in the incident cohort. Exclusions comprised patients diagnosed with UC in the first 365\u2009days or with myocardial infarction, heart failure, stroke, or other ischemic heart diseases within 30\u2009days pre\u2010index. The cumulative incidence rate of MACE was calculated using the Kaplan\u2013Meier method. Multivariate Cox regression models were used to calculate hazard ratios (HRs) for all relevant potential risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 11\u2009407 patients in the incident cohort, 91 (0.8%) experienced incident MACE. Over 120\u2009months, the cumulative incidence rate of MACE was 2.86% (95% confidence interval [CI]: 1.89\u20134.32). Significant HRs (95% CI) were found for age category (\u2265\u200965\u2009years) (4.557 [2.786\u20137.452]), diabetes (1.709 [1.030\u20132.835]), and atrial fibrillation (AF) (2.759 [1.188\u20136.405]) (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Patients with a history of stroke showed numerically increased risk (1.871 [0.508\u20136.886]) of MACE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The cumulative incidence rate of MACE was 2.86% over 120\u2009months. Age, comorbidities of diabetes and AF, and history of stroke were the major risk factors for MACE in Japanese UC patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16831","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T08:34:03Z","timestamp":1733992443000},"page":"421-432","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Identifying Risk Factors of Major Adverse Cardiac Events in Patients With Ulcerative Colitis: A Retrospective Japanese Claims Data Analysis"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6119-4828","authenticated-orcid":false,"given":"Tomohisa","family":"Takagi","sequence":"first","affiliation":[{"name":"Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0466-5993","authenticated-orcid":false,"given":"Linghua","family":"Xu","sequence":"additional","affiliation":[{"name":"Access and Value, Outcome and Evidence Pfizer Japan Inc.  Shibuya City Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2874-1807","authenticated-orcid":false,"given":"Masato","family":"Hoshi","sequence":"additional","affiliation":[{"name":"Specialty Care Medical Affairs Pfizer Japan Inc.  Shibuya City Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4609-1609","authenticated-orcid":false,"given":"Shoko","family":"Arai","sequence":"additional","affiliation":[{"name":"Specialty Care Medical Affairs Pfizer Japan Inc.  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