{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:11:21Z","timestamp":1787015481441,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Studies have reported the benefits of tranexamic acid (TXA) in controlling bleeding across various conditions. However, the effect of TXA in upper gastrointestinal bleeding (UGIB) remains controversial, and its therapeutic impact when combined with acid suppression, particularly proton pump inhibitors (PPIs), which are considered first\u2010line therapy for bleeding peptic ulcers, has not been reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We systematically searched PubMed, Embase, and Google Scholar from January 1987 to June 2024 using predefined keywords to identify RCTs meeting our inclusion criteria, including details of TXA dosage, route of administration, and choice of acid suppressants. Data from selected trials were extracted, and a meta\u2010analysis was performed using random\u2010effects modeling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Six trials with 709 participants were included. Baseline patient characteristics in the selected trials were balanced. The rebleeding rate, mortality, need for blood transfusion, units of blood transfused, and need for salvage therapy were compared. The TXA with acid suppression group significantly reduced the risk of rebleeding (RR: 0.63, 95% CI: 0.41\u20130.96), units of blood transfused (mean difference: \u22121.08, 95% CI: \u22121.44 to \u22120.71), and the need for salvage therapy (RR: 0.28, 95% CI: 0.12\u20130.64). No significant difference was observed in mortality rate (RR: 0.74) and need for blood transfusion (RR: 1.01) between the two groups, but outcomes favored the TXA and acid suppression group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We suggest combining TXA with acid suppression as a first\u2010line therapy for UGIB patients. Further trials should be conducted to determine the optimal dose and route of TXA administration for better care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.16842","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T06:16:11Z","timestamp":1733292971000},"page":"398-403","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Tranexamic Acid With Acid Suppression Versus Acid Suppression Alone as Therapy for Upper Gastrointestinal Bleeding: A Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1111","volume":"40","author":[{"given":"Sheau\u2010Wen","family":"Kan","sequence":"first","affiliation":[{"name":"Division of Emergency Medicine, Department of Emergency and Critical Care Taipei Medical University\u2010Shuang Ho Hospital  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen\u00a0Pin","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of General Surgery Tan Tock Seng Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u00a0Zhe","family":"Tay","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Taipei Medical University\u2010Shuang Ho Hospital  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0560-4471","authenticated-orcid":false,"given":"Mei\u2010Ju","family":"Chi","sequence":"additional","affiliation":[{"name":"School of Gerontology and Long\u2010Term Care, College of Nursing Taipei Medical University  Taipei Taiwan"},{"name":"International PhD Program in Gerontology and Long\u2010Term Care, College of Nursing Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2023.08.010"},{"key":"e_1_2_7_3_1","volume-title":"StatPearls","author":"Antunes C.","year":"2024"},{"issue":"9","key":"e_1_2_7_4_1","first-page":"1449","article-title":"Improving Quality of Care in Peptic Ulcer Bleeding: Nationwide Cohort Study of 13,498 Consecutive Patients in the Danish Clinical Register of Emergency","volume":"108","author":"Rosenstock S. 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