{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T20:15:48Z","timestamp":1788466548534,"version":"build-2803163510"},"reference-count":56,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,12,15]],"date-time":"2024-12-15T00:00:00Z","timestamp":1734220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,12,15]],"date-time":"2024-12-15T00:00:00Z","timestamp":1734220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cholecystectomy (CCE) can affect the enterohepatic circulation of bile acids and result in gut microbiome changes. This systematic review aimed to clarify the effect of CCE on gut microbiome composition and its clinical impact.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A systematic search was conducted in PubMed, Web of Science, and Scopus, combining keywords such as \u201ccholecystectomy\u201d or \u201cpost\u2010cholecystectomy\u201d with \u201cgut microbiome,\u201d \u201cstool microbiome,\u201d or \u201cgut dysbiosis.\u201d Data were extracted and synthesized using narrative review. Study quality was assessed using the Newcastle\u2010Ottawa scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1373 articles were screened and 14 studies were selected. Significant but inconsistent microbiome changes were reported. Changes were observed in alpha and beta diversity. At phylum level, an increase in Bacteroides and Ascomycota, decrease in Firmicutes, Actinomycetes, and Basidiomycota, and both increase and decrease in Fusobacteria were reported. At genus level, an increase in\n                      <jats:italic>Prevotella<\/jats:italic>\n                      and a decrease in\n                      <jats:italic>Faecalibacterium<\/jats:italic>\n                      were reported. In post\u2010CCE diarrhea, decreased beta diversity, a decreased F\/B ratio, an increase in\n                      <jats:italic>Prevotella<\/jats:italic>\n                      , an increase in\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Phocaeicola vulgatus<\/jats:italic>\n                      <\/jats:styled-content>\n                      , and a decrease in\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Prevotella copri<\/jats:italic>\n                      <\/jats:styled-content>\n                      were noted. For post\u2010CCE syndrome, a higher abundance of Proteobacteria and decreased Firmicutes\/Bacteroides (F\/B)\u00a0ratio were reported. A decreased relative abundance of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Bifidobacterium longum<\/jats:italic>\n                      <\/jats:styled-content>\n                      <jats:italic>subsp<\/jats:italic>\n                      .\n                      <jats:italic>longum<\/jats:italic>\n                      from controls to CCE without colonic neoplasia to CCE with colonic neoplasia, and an increased abundance of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Candida\u2009glabrata<\/jats:italic>\n                      <\/jats:styled-content>\n                      from controls, to CCE without colonic neoplasia and CCE with colonic neoplasia, were reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients who underwent CCE had significant gut dysbiosis. However, current studies could not clarify the detailed gut microbial structural and functional changes associated with CCE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.16846","type":"journal-article","created":{"date-parts":[[2024,12,15]],"date-time":"2024-12-15T20:33:16Z","timestamp":1734294796000},"page":"574-583","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Postcholecystectomy Gut Microbiome Changes and the Clinical Impact: A Systematic Review With Narrative Synthesis"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9993-8549","authenticated-orcid":false,"given":"Tiing\u00a0Leong","family":"Ang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Changi General Hospital  Singapore"},{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore"},{"name":"Duke\u2010NUS Medical School  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