{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T07:18:35Z","timestamp":1787987915841,"version":"build-2784847793"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Prognosis in autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC) has historically been poor. This multicenter retrospective cohort study investigated the natural history and assessed the predictors of outcomes in patients with AIH, PBC, and PSC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>AIH, PBC, and PSC patients were identified from the state\u2010wide Hepascore and Clinical Outcome cohort. Overall death or transplant, liver\u2010related mortality (liver\u2010related death or transplant), and liver\u2010related decompensation were determined using a population\u2010based data linkage system. Baseline Liver Outcome Score (LOS), Hepascore, and MELD were examined for predicting outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two\u2010hundred thirty\u2010seven AIH patients (24% male, median age 56.6\u2009years [range, 14.3\u201394.0]), 157 PBC patients (8.3% male, median age 60.5\u2009years [range, 25.6\u201387.1]), and 167 PSC patients (52.7% male, median age 55.6\u2009years [range, 18.4\u201388.6]) were enrolled. Five\u2010year transplant\u2010free survival was 88% (95%CI: 81\u201392%) in AIH, 92% (95%CI: 85\u201396%) in PBC, and 61% (95%CI: 51\u201369%) in PSC. PSC had a significantly worse overall death or transplant, liver\u2010related mortality, and liver\u2010related decompensation when compared to AIH and PBC (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). LOS was a significant independent predictor of overall death or transplant, liver\u2010related mortality, and liver\u2010related decompensation among patients with AIH and PBC. LOS was a significant independent predictor of overall death or transplant in patients with PSC, and Hepascore was a significant independent predictor of liver\u2010related mortality and liver\u2010related decompensation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Outcomes for AIH and PBC are excellent but remain poor in PSC. LOS is a predictor of outcomes in autoimmune liver disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.16850","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T03:45:46Z","timestamp":1734407146000},"page":"731-740","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Natural History and Predictors of Clinical Outcomes in Autoimmune Liver Diseases: A Multicenter Study"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9722-661X","authenticated-orcid":false,"given":"Dujinthan","family":"Jayabalan","sequence":"first","affiliation":[{"name":"Department of Hepatology Sir Charles Gairdner Hospital  Nedlands Western Australia Australia"},{"name":"Medical School The University of Western Australia  Nedlands Western Australia 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