{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T23:07:15Z","timestamp":1780096035795,"version":"3.54.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T00:00:00Z","timestamp":1739232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T00:00:00Z","timestamp":1739232000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Brush cytology is a widely used diagnostic method in conjunction with intraductal biopsies during endoscopic retrograde cholangiopancreatography, but its diagnostic yield remains a limitation. This study evaluated the efficacy of biliary cytology using a newly developed brush device with rapid on\u2010site cytological evaluation (ROSE) for detecting malignant biliary strictures (MBSs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In total, 58 patients with suspected intrinsic MBS identified by intraductal ultrasound were enrolled. After achieving tissue sampling with ROSE through a maximum of two brushing passes, a transpapillary forceps biopsy (TPB) was performed. The primary outcome was diagnostic accuracy, and the secondary outcomes were technical success, sampling adequacy, and procedure\u2010related adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Biliary cytology with ROSE was technically successful in all patients (58\/58), with a sampling adequacy of 96.6% (56\/58). The technical success and sampling adequacy of TPB were 94.8% (55\/58) and 91.4% (53\/58), respectively. Brush cytology with ROSE and TPB yielded sensitivity rates of 91.8% and 85.7%, specificity rates of 88.9% for both, and accuracy rates of 88.9% for both. The receiver operating characteristic curve comparing the diagnostic accuracies of brush cytology with ROSE and TPB combined versus TPB alone showed a significantly higher value for the combined approach (0.93) than TPB alone (0.87) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Biliary brush cytology using a novel brush device with ROSE is effective and can be used complementarily to TPB in patients with suspected MBS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.16865","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T01:05:16Z","timestamp":1739322316000},"page":"750-756","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of Biliary Brush Cytology With Rapid On\u2010Site Cytological Evaluation for the Detection of Malignant Biliary Strictures"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2199-1942","authenticated-orcid":false,"given":"Il\u00a0Sang","family":"Shin","sequence":"first","affiliation":[{"name":"Digestive Disease Center and Research Institute, Department of Internal Medicine SoonChunHyang University School of Medicine  Bucheon, Cheonan, and Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u00a0Ho","family":"Myeong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Catholic Kwandong University College of Medicine  Incheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3946-9944","authenticated-orcid":false,"given":"Jong\u00a0Ho","family":"Moon","sequence":"additional","affiliation":[{"name":"Digestive Disease Center and Research Institute, Department of Internal Medicine SoonChunHyang University School of Medicine  Bucheon, Cheonan, and Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun\u00a0Nah","family":"Lee","sequence":"additional","affiliation":[{"name":"Digestive Disease Center and Research Institute, Department of Internal Medicine SoonChunHyang University School of Medicine  Bucheon, Cheonan, and Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae\u00a0Woo","family":"Park","sequence":"additional","affiliation":[{"name":"Digestive Disease Center and Research Institute, Department of Internal Medicine SoonChunHyang University School of Medicine  Bucheon, Cheonan, and Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee\u00a0Kyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Pathology SoonChunHyang University School of Medicine  Bucheon South 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