{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T08:49:25Z","timestamp":1772614165593,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Opinions about the impact of bowel preparation on the gut microbiota are divided. This study investigated the effects of different regimens on the gut microbiota post\u2010bowel preparation and the differences in responses across different age groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This single\u2010center, prospective, randomized, controlled clinical trial included 194 patients. Patients were categorized into two groups: one group receiving polyethylene glycol (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009108) and one receiving sodium picosulfate (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200986) for bowel preparation. Fecal samples were collected at baseline and on days 7 and 14 post\u2010bowel preparation. The microbiota's diversity and composition were analyzed using 16S ribosomal RNA gene sequencing, followed by comparative analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The gut microbiota's abundance and diversity in patients significantly decreased post\u2010bowel preparation, which did not recover to the level of pre\u2010bowel preparation on Day 14. When comparing different regimens, the polyethylene glycol and sodium picosulfate groups recovered faster in richness and diversity, respectively. Patients aged &lt;\u200965\u2009years had higher richness and diversity of the gut microbiota, whereas the microbiota structure in those aged \u2265\u200965\u2009years returned to the baseline state faster. The structure of beta diversity is significantly altered and did not return in the short term. However, in the elderly population aged \u2265\u200965\u2009years, it can rebound quickly. This study also identified a number of significantly altered bacterial genera.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Following the use of different bowel preparation regimens, the gut microbiota recovers in diverse ways, with older people over 65 experiencing a faster recovery of the microbial structure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.16868","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T20:15:47Z","timestamp":1736367347000},"page":"599-608","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of Different Bowel Preparation Regimens and Age Factors on the Gut Microbiota: A Prospective Randomized Controlled Study"],"prefix":"10.1111","volume":"40","author":[{"given":"Yuhang","family":"Zhou","sequence":"first","affiliation":[{"name":"China\u2013Japan Friendship Hospital (Institute of Clinical Medical Sciences) Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"},{"name":"Department of Gastroenterology China\u2013Japan Friendship Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huihui","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology China\u2013Japan Friendship Hospital  Beijing China"},{"name":"Peking University China\u2013Japan Friendship School of Clinical Medicine  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology China\u2013Japan Friendship Hospital  Beijing China"},{"name":"China\u2013Japan Friendship Hospital Beijing University of Chinese 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