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Published cases have reported extensive biopsychosocial comorbidities accompanying delayed diagnosis and incomplete management; these include social rejection and family separation, court\u2010ordered alcohol rehabilitation and psychiatric admission, legal and employment ramifications, and deteriorating mental health and suicidality. In this mini review, we aim to educate and enlighten clinicians by discussing literature findings pertaining to the pathophysiological mechanisms of gut dysbiosis due to overgrowth of <jats:styled-content style=\"fixed-case\"><jats:italic>Saccharomyces cerevisiae<\/jats:italic><\/jats:styled-content>, <jats:italic>E. coli<\/jats:italic> and <jats:italic>Klebsiella<\/jats:italic>, impaired intestinal barrier function, and dysregulation of the hypothalamic\u2013pituitary\u2013adrenal axis. Furthermore, we discuss recently discovered associations with sleep quality and mood disorders and explore the medical sequelae of metabolic dysfunction\u2010associated fatty liver disease and metabolic dysfunction\u2010associated steatohepatitis. Drawing on these data, we propose protocols for initial care in the emergency room, subsequent critical care, diagnostic testing with glucose challenge testing, and definitive microbiological testing during the acute phase of illness. We also present an empirical treatment outline while awaiting confirmation of causative organisms and sensitivities.<\/jats:p>","DOI":"10.1111\/jgh.16869","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T05:52:54Z","timestamp":1737697974000},"page":"783-790","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Endogenous Ethanol Production in the Human Alimentary Tract: A Literature Review"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6510-473X","authenticated-orcid":false,"given":"Renee","family":"Stamation","sequence":"first","affiliation":[{"name":"Department of Rural Health University of Melbourne, Echuca Clinical School  Echuca Victoria 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