{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T09:07:17Z","timestamp":1769850437994,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002873","name":"Chulalongkorn University","doi-asserted-by":"publisher","award":["CU\u2010GRS\u201062\u201002\u201030\u201001"],"award-info":[{"award-number":["CU\u2010GRS\u201062\u201002\u201030\u201001"]}],"id":[{"id":"10.13039\/501100002873","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Guidelines recommend endoscopic surveillance for gastric cancer without therapeutic intervention every 3\u2009years in patients with high\u2010risk gastric intestinal metaplasia (GIM). This study aimed to evaluate the efficacy of radiofrequency ablation (RFA) in eradicating high\u2010risk GIM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This randomized self\u2010control trial was conducted between June 2020 and February 2023. Patients with histology\u2010verified high\u2010risk GIM were enrolled. The endoscopist performed a biopsy on both the left and right sides of the stomach (five each) by targeting the suspected GIM area where available; otherwise, a random biopsy was taken. Patients were randomized to receive a unilateral RFA on either the left or right side. A repeated RFA on the assigned side was performed every 2\u20133\u2009months for a total of two to three times. The primary outcome was complete resolution of GIM at 1\u2009year after RFA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010six patients with a mean age of 66\u2009\u00b1\u20098\u2009years were analyzed. The complete resolution rate of overall GIM lesions after RFA was significantly higher (49\/142; 34\/5%) than that in the observation group (29\/127; 22.8%, RR\u2009=\u20090.84, 0.73\u20130.98, <jats:italic>p<\/jats:italic>\u2009=\u20090.03). For the subgroup analysis, the complete resolution rate after RFA revealed a significantly higher value than observation only in the incomplete GIM group (24\/87; 27.6% vs. 11\/82; 13.4%, RR\u2009=\u20090.83, 0.71\u20130.97, <jats:italic>p<\/jats:italic>\u2009=\u20090.02). The percentage of patients with extensive GIM regression after RFA (15\/25; 60%) was higher than in the observation group (9\/25; 36%) but did not meet statistical significance (RR\u2009=\u20090.62, 0.35\u20131.09, <jats:italic>p<\/jats:italic>\u2009=\u20090.09).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In high\u2010risk GIM, RFA can significantly eradicate incomplete GIM when compared with observation alone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16875","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T04:39:07Z","timestamp":1736224747000},"page":"891-899","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy of Radiofrequency Ablation as a Treatment for High\u2010Risk Gastric Intestinal Metaplasia: A Randomized, Self\u2010Control Study"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6407-5245","authenticated-orcid":false,"given":"Rapat","family":"Pittayanon","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Faculty of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital, The Thai Red Cross  Bangkok Thailand"},{"name":"Center of Excellence for Innovation and Endoscopy in Gastrointestinal Oncology Chulalongkorn University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8550-8142","authenticated-orcid":false,"given":"Kasenee","family":"Tiankanon","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Faculty of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital, The Thai Red Cross  Bangkok Thailand"},{"name":"Center of Excellence for Innovation and Endoscopy in Gastrointestinal Oncology Chulalongkorn University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natee","family":"Faknak","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Faculty of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital, The Thai Red Cross  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathawadee","family":"Lerttanatum","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital, The Thai Red Cross Society  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anapat","family":"Sanpavat","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital, The Thai Red Cross Society  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naruemon","family":"Klaikaew","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital, The Thai Red Cross Society  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6866-6886","authenticated-orcid":false,"given":"Rungsun","family":"Rerknimitr","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Faculty of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital, The Thai Red Cross  Bangkok Thailand"},{"name":"Center of Excellence for Innovation and Endoscopy in Gastrointestinal Oncology Chulalongkorn University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-2980.2011.00550.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.12.002"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-318126"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.12.003"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0859-1883"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.01.030"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.322"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.03.039"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/9394381"},{"key":"e_1_2_9_12_1","first-page":"748","article-title":"Treatment of Gastric Metaplasia or Dysplasia by Endoscopic Radiofrequency Ablation: A Pilot Study","volume":"62","author":"Leung W. 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