{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T09:42:16Z","timestamp":1781343736727,"version":"3.54.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["22Y11907500"],"award-info":[{"award-number":["22Y11907500"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["22015831400"],"award-info":[{"award-number":["22015831400"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81900548"],"award-info":[{"award-number":["81900548"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370546"],"award-info":[{"award-number":["82370546"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>This work aims to evaluate the efficacy and safety of free\u2010hand endoscopic full\u2010thickness resection (EFTR) for duodenal subepithelial lesions (SELs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective review of 105 patients with duodenal SELs who underwent free\u2010hand EFTR. Free\u2010hand EFTR means no other devices (over\u2010the\u2010scope clip or full\u2010thickness resection device) are required. The preoperative baseline data, procedure\u2010related characteristics, and postoperative outcomes were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The technical success rate was 99.0%, and the en bloc resection rate was 94.2%. A total of nine (8.7%) patients experienced major postoperative adverse events (AEs). The incidence of major AEs was significantly higher for lesions with a maximum diameter \u2265\u20092\u2009cm (30.4%) than for lesions with a maximum diameter &lt;\u20092\u2009cm (2.6%) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). There were also significant differences in the incidence of major AEs for peri\u2010ampullary lesions (37.5%), bulb lesions (4.8%), bulb\u2010descending junction lesions (6.7%), and descending part lesions (12.5%) (<jats:italic>p<\/jats:italic>\u2009=\u20090.032). Multivariable regression analyses revealed that the maximum diameter \u2265\u20092\u2009cm (OR\u2009=\u200918.108; 95% CI\u2009=\u20091.881\u2013174.281; <jats:italic>p<\/jats:italic>\u2009=\u20090.012) and lesions located in peri\u2010ampullary (OR\u2009=\u200918.950; 95% CI\u2009=\u20091.219\u2013294.648; <jats:italic>p<\/jats:italic>\u2009=\u20090.036) were independent risk factors for major AEs. The mean duration of the follow\u2010up period was 36.6\u2009\u00b1\u200921.3\u2009months, and only one patient with gastrointestinal stromal tumors recurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Free\u2010hand EFTR is a safe and effective technique for nonampullary duodenal SELs with a maximum diameter of &lt;\u20092\u2009cm. Given the complexity of the duodenal anatomy, this procedure should be performed by experienced endoscopists.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16878","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T05:14:23Z","timestamp":1737609263000},"page":"907-916","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Free\u2010Hand Endoscopic Full\u2010Thickness Resection for Duodenal Subepithelial Lesions"],"prefix":"10.1111","volume":"40","author":[{"given":"Peirong","family":"Xu","sequence":"first","affiliation":[{"name":"Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital Fudan University  Shanghai China"},{"name":"Endoscopy Center of Zhongshan Hospital Shanghai Collaborative Innovation Center of Endoscopy  Shanghai 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Hospital Shanghai Collaborative Innovation Center of Endoscopy  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenchao","family":"Xu","sequence":"additional","affiliation":[{"name":"Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital Fudan University  Shanghai China"},{"name":"Endoscopy Center of Zhongshan Hospital Shanghai Collaborative Innovation Center of Endoscopy  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anyi","family":"Xiang","sequence":"additional","affiliation":[{"name":"Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital Fudan University  Shanghai China"},{"name":"Endoscopy Center of Zhongshan Hospital Shanghai Collaborative Innovation Center of Endoscopy  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Su","sequence":"additional","affiliation":[{"name":"Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital Fudan University  Shanghai China"},{"name":"Endoscopy Center of Zhongshan Hospital Shanghai Collaborative Innovation Center of Endoscopy  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Tan","sequence":"additional","affiliation":[{"name":"Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital Fudan University  Shanghai China"},{"name":"Endoscopy Center of Zhongshan Hospital Shanghai Collaborative Innovation Center of Endoscopy  Shanghai China"},{"name":"School of Health Science and Engineering University of Shanghai for Science and Technology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital Fudan University  Shanghai China"},{"name":"Endoscopy Center of Zhongshan Hospital Shanghai Collaborative Innovation Center of Endoscopy  Shanghai 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