{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:40:12Z","timestamp":1791567612148,"version":"4.3.4"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Colorectal cancer (CRC) is a significant global health burden, and screening can greatly reduce CRC incidence and mortality. Previous studies investigated the economic effects of CRC screening. We performed a systematic review to provide the cost\u2010effectiveness of CRC screening strategies across countries with different income levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched relevant scientific databases (PubMed, Embase, Ovid, Web of Science, Scopus) from January 1, 2010, to December 31, 2023. We selected English\u2010language studies related to model\u2010based economic evaluations of CRC screening strategies. Information such as the characters of screening tests, model characteristics, and key cost\u2010effectiveness findings were collected. The net monetary benefit approach was used to compare the outcomes of various strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 56 studies were identified, including 46 from high\u2010income countries (HICs), 6 from upper\u2010middle\u2010income countries (UMICs), and 4 from lower\u2010middle\u2010income countries (LMICs). Most annual fecal occult blood tests and fecal immunochemical tests were cost\u2010saving, and colonoscopy every 10\u2009years was cost\u2010saving. Other strategies involving multitarget fecal FIT\u2010DNA detection, computed tomography colonography, and flexible sigmoidoscopy were cost\u2010effective compared with no screening. Newer strategies such as magnetic resonance colonography every 5\u2009years, annual urine metabolomic tests, and fecal bacterial biomarkers were cost\u2010effective compared with no screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In our updated review, we found that common CRC screening strategies and magnetic resonance colonography continued to be cost\u2010effective compared with no screening. Areas for further development include accurately modeling the natural history of colorectal cancer and obtaining more evidence from UMICs and LMICs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.16882","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T05:51:16Z","timestamp":1737006676000},"page":"584-598","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Cost Effectiveness of Colorectal Cancer Screening Strategies in Middle\u2010 and High\u2010Income Countries: A Systematic Review"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3773-6703","authenticated-orcid":false,"given":"Yuxuan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Xi'an Jiaotong University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruyi","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Xi'an Jiaotong University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Si","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Xi'an Jiaotong University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Xi'an Jiaotong University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunbo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Xi'an Jiaotong University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guihua","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Xi'an Jiaotong University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2021.09.034"},{"key":"e_1_2_8_4_1","unstructured":"Cancer IAfRo.Globocan 2020: Cancer Fact Sheets\u2010Colorectal Cancer. 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