{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T13:50:20Z","timestamp":1781617820598,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Acute\u2010on\u2010chronic liver failure (ACLF) is a complex syndrome with limited treatment options. This study aims to investigate the impact of artificial liver support system (ALSS) on the one\u2010year prognosis of patients with Hepatitis B virus (HBV)\u2010associated ACLF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A retrospective study was conducted on 239 patients with HBV\u2010ACLF in Nanfang Hospital from January 2016 to June 2021. Patients were divided into the ALSS group (<jats:italic>n<\/jats:italic>\u2009=\u2009103) and the Standard Medical Therapy (SMT group, <jats:italic>n<\/jats:italic>\u2009=\u2009136). Demographic, clinical, and laboratory data were collected before the first ALSS treatment for patients in ALSS group, while baseline data were collected in SMT group. According to receiving different ALSS modes, patients in ALSS group were divided into plasma exchange (PE) group and non\u2010PE group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>The 12\u2010week and 1\u2010year liver transplant (LT) free survival rates in the ALSS group were significantly higher than that in the SMT group (65.05% vs 52.21%, <jats:italic>p<\/jats:italic>\u2009=\u20090.0011; 63.11% vs. 48.53%, <jats:italic>p<\/jats:italic>\u2009=\u20090.0006). ALSS therapy was the independent predictive factors associated with 12\u2010week and 1\u2010year mortality (hazard ratio, HR: 0.59, <jats:italic>p<\/jats:italic>\u2009=\u20090.04, and HR: 0.54, <jats:italic>p<\/jats:italic>\u2009=\u20090.01). Comparatively more ALSS\u2010related complications were observed in PE group. After Propensity Score Matching, the 12\u2010week and 1\u2010year LT\u2010free survival rates between PE and non\u2010PE group were similar (88% vs. 80%, <jats:italic>p<\/jats:italic>\u2009=\u20090.227, 88% vs. 80%, <jats:italic>p<\/jats:italic>\u2009=\u20090.227).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ALSS therapy is a safe and effective treatment for HBV\u2010ACLF. ALSS improves 1\u2010year prognosis of patients with HBV\u2010ACLF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16883","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T06:10:27Z","timestamp":1738044627000},"page":"940-948","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Artificial Liver Support System Improves One\u2010Year Prognosis of Patients With Hepatitis B Virus\u2010Associated Acute\u2010on\u2010Chronic Liver Failure"],"prefix":"10.1111","volume":"40","author":[{"given":"Xiaoqin","family":"Lan","sequence":"first","affiliation":[{"name":"Hepatology Unit, Nanfang Hospital, Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9324-2680","authenticated-orcid":false,"given":"Changze","family":"Hong","sequence":"additional","affiliation":[{"name":"Hepatology Unit, Nanfang Hospital, Southern 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