{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:31:19Z","timestamp":1791311479012,"version":"4.3.1"},"reference-count":104,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To identify factors influencing HBsAg seroclearance rates after stopping nucleos(t)ide analogue (NA) therapy in patients with chronic hepatitis B (CHB).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a comprehensive literature search in databases from inception to July 2024. Subgroup analyses and meta\u2010regression were performed to determine factors associated with HBsAg seroclearance, including ethnicity, HBV genotype, NA therapy duration, end\u2010of\u2010treatment (EOT) qHBsAg levels, HBeAg status, cirrhosis status, and follow\u2010up duration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The meta\u2010analysis included 62 studies (<jats:italic>n<\/jats:italic>\u2009=\u20099867) with a pooled HBsAg seroclearance rate of 10% (95%CI: 8%\u201312%, <jats:italic>I<\/jats:italic><jats:sup><jats:italic>2<\/jats:italic><\/jats:sup>\u2009=\u200992%) after NA cessation. HBeAg\u2010negative patients showed significantly higher rates than HBeAg\u2010positive patients (11% vs. 5%, <jats:italic>p<\/jats:italic>\u2009=\u20090.030). Subgroup analysis revealed higher seroclearance with follow\u2010up of &gt;5\u2009years (18%, <jats:italic>p<\/jats:italic>\u2009=\u20090.004), showing significantly higher rates were observed in studies with longer follow\u2010up periods. Caucasians showed a higher rate (12%) than Asians (9%, <jats:italic>p<\/jats:italic>\u2009=\u20090.067). Studies adhering to AASLD, EASL, or APASL stopping rules showed no significant differences in rates. Patients with EOT qHBsAg \u22642.0 log IU\/mL had higher rates (23%) than those with &gt;2.0 log IU\/mL (11%). Re\u2010treated patients had lower seroclearance (6%) compared to those not re\u2010treated (17%, <jats:italic>p<\/jats:italic>\u2009=\u20090.178). Meta\u2010regression identified ethnicity, HBeAg status, and follow\u2010up duration as significant contributors to heterogeneity. Egger's test showed no evidence of publication bias (<jats:italic>p<\/jats:italic>\u2009=\u20090.1928).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our meta\u2010analysis highlights the role of ethnicity, EOT qHBsAg levels, HBeAg\u2010status, and follow\u2010up duration in determining HBsAg seroclearance rates. These findings stress the need for personalized NA discontinuation strategies and further research on HBV genotypes and biomarkers to improve treatment outcomes and predict seroclearance more accurately.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16920","type":"journal-article","created":{"date-parts":[[2025,3,9]],"date-time":"2025-03-09T14:17:58Z","timestamp":1741529878000},"page":"1079-1104","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Hepatitis B Surface Antigen Seroclearance Rate After Stopping Nucleos(t)ide Analogues in Chronic Hepatitis B\u2014A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"40","author":[{"given":"Soe\u00a0Thiha","family":"Maung","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, King Chulalongkorn Memorial Hospital and Thai Red Cross Society Faculty of Medicine, Chulalongkorn University  Bangkok Thailand"},{"name":"Ma Har Myaing Hospital  Yangon Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pakanat","family":"Decharatanachart","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, King Chulalongkorn Memorial Hospital and Thai Red Cross Society Faculty of Medicine, Chulalongkorn University  Bangkok Thailand"},{"name":"Division of Academic Affairs Faculty of Medicine, Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7191-3881","authenticated-orcid":false,"given":"Roongruedee","family":"Chaiteerakij","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, King Chulalongkorn Memorial Hospital and Thai Red Cross Society Faculty of Medicine, Chulalongkorn University  Bangkok Thailand"},{"name":"Center of Excellence for Innovation and Endoscopy in Gastrointestinal Oncology Faculty of Medicine, Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(22)00386-7"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(23)00197-8"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30204-3"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.10.008"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31030"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(18)30308-X"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.10.027"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-305517"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29800"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.03.021"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-015-9675-4"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.05.039"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-008-9080-3"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-012-9365-4"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-021-10223-5"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11901-024-00663-6"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13272"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28438"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30474"},{"issue":"8","key":"e_1_2_11_21_1","first-page":"1629","article-title":"Discontinuation of Nucleot(S)ide Analogue Therapy in HBeAg\u2010Negative Chronic Hepatitis B: A meta\u2010Analysis","volume":"71","author":"Hall S. 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