{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:08:29Z","timestamp":1787162909674,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004738","name":"E-Da Hospital","doi-asserted-by":"publisher","award":["EDAHS113028"],"award-info":[{"award-number":["EDAHS113028"]}],"id":[{"id":"10.13039\/501100004738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>The relapse pattern following the discontinuation of tenofovir alafenamide (TAF) in patients with chronic hepatitis B (CHB) remains unclear. This study aimed to compare the 2\u2010year incidences of virological and clinical relapses among patients who discontinued TAF versus those who discontinued tenofovir disoproxil fumarate (TDF) or entecavir (ETV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter retrospective study enrolled noncirrhotic hepatitis B e antigen (HBeAg)\u2010negative CHB patients who discontinued TAF, TDF, or ETV with undetectable HBV DNA at treatment cessation. For patients who switched from ETV or TDF to TAF, a minimum TAF exposure duration of 12\u2009months was required for inclusion in the off\u2010TAF group. Inverse probability of treatment weighting was employed to adjust for baseline differences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 162 patients (off\u2010TAF: 37, off\u2010TDF: 87, off\u2010ETV: 38) were included in the primary analysis. The 2\u2010year cumulative incidence of virological relapse was significantly higher in the off\u2010TAF group (85.0%) compared to the off\u2010TDF group (69.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.024) and the off\u2010ETV group (51.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010). Similarly, the 2\u2010year cumulative incidence of clinical relapse was significantly higher in the off\u2010TAF group (62.4%) compared to the off\u2010TDF group (39.0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.026) and the off\u2010ETV group (22.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.024). Consistent results were observed in patients meeting the 2012 APASL stopping criteria.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HBeAg\u2010negative patients who discontinue TAF face a higher risk of both virological and clinical relapses compared to those discontinuing TDF or ETV. These findings underscore the need for more intense monitoring in CHB patients after TAF cessation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.16923","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T21:24:30Z","timestamp":1741728270000},"page":"1245-1254","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Incidences of Virological and Clinical Relapses After Cessation of Tenofovir Alafenamide, Tenofovir Disoproxil Fumarate, or Entecavir in Patients With HBeAg\u2010Negative Chronic Hepatitis B"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4507-2414","authenticated-orcid":false,"given":"Cheng\u2010Hao","family":"Tseng","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology E\u2010DA Cancer Hospital  Kaohsiung Taiwan"},{"name":"Division of Gastroenterology and Hepatology E\u2010DA Hospital  Kaohsiung Taiwan"},{"name":"School of Medicine, College of Medicine I\u2010Shou University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4097-4315","authenticated-orcid":false,"given":"Teng\u2010Yu","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Medicine Chung Shan Medical University  Taichung Taiwan"},{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Taichung Veterans General Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Ditmanson Medical Foundation Chia\u2010Yi Christian Hospital  Chia\u2010Yi Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3367-068X","authenticated-orcid":false,"given":"Chung\u2010Feng","family":"Huang","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po\u2010Yueh","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Ditmanson Medical Foundation Chia\u2010Yi Christian Hospital  Chia\u2010Yi Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2961-130X","authenticated-orcid":false,"given":"Tyng\u2010Yuan","family":"Jang","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzeng\u2010Huey","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Lotung Poh\u2010Ai Hospital  Yilan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Ching","family":"Wu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Medicine I\u2010Shou University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8984-5103","authenticated-orcid":false,"given":"Yao\u2010Chun","family":"Hsu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology E\u2010DA Hospital  Kaohsiung Taiwan"},{"name":"School of Medicine, College of Medicine I\u2010Shou University  Kaohsiung Taiwan"},{"name":"Graduate Institute of Medicine I\u2010Shou University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,3]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"World Health Organization \u201cHepatitis B \u201d World Health Organization."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26180"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28280"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiy391"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26301"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiab241"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-305517"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.03.021"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-015-9675-4"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29800"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-019-09991-y"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiy697"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29640"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002203"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.17614"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2022.100617"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1729973"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-021-10223-5"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.04.048"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2022.07.005"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15058"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15053"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15140"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix690"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2023.01.154"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11030752"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.11.002"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.12.005"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-012-9365-4"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312653"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2010.37"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-307237"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2022.0420"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30474"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.16923","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T09:31:58Z","timestamp":1748338318000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.16923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,3]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/jgh.16923"],"URL":"https:\/\/doi.org\/10.1111\/jgh.16923","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,3]]},"assertion":[{"value":"2024-12-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}