{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:17:13Z","timestamp":1791951433258,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:00:00Z","timestamp":1741305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022 M710752"],"award-info":[{"award-number":["2022 M710752"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Although platinum\u2010based chemotherapy represented by cisplatin has been widely approved for the management of diverse cancer types, its hepatotoxicity and other adverse effects impact patient prognosis, while currently, there are few effective strategies for prevention or treatment. RNA sequencing analysis indicated that the type I interferon (IFN\u2010I) pathway was significantly upregulated in cisplatin\u2010induced liver injury (CILI) mouse model. The cGAS\u2010STING signaling was found to be significantly activated in\u00a0vitro and CILI model in\u00a0vivo. Mechanistically, cisplatin\u2010induced DNA damage triggered the release of double\u2010stranded DNA (dsDNA), which subsequently activated the cGAS\u2010STING pathway. The activated pathway promoted the production of IFN\u2010I and induced apoptosis, ultimately contributing to liver injury. Importantly, inhibition of the cGAS\u2010STING pathway, either by enzymatic digestion of dsDNA or by genetic knockout of cGAS, effectively attenuated IFN\u2010I production and liver injury in response to cisplatin. Overall, our results highlight the cGAS\u2010STING\u2010IFN\u2010I axis as a promising therapeutic target for preventing and treating platinum\u2010based drug\u2010induced liver damage.<\/jats:p>","DOI":"10.1111\/jgh.16926","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T11:45:35Z","timestamp":1741693535000},"page":"1283-1296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cisplatin Promotes Hepatotoxicity by cGAS\u2010STING Mediated Innate Immune Response"],"prefix":"10.1111","volume":"40","author":[{"given":"Qiongyan","family":"Tao","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genwen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2915-9114","authenticated-orcid":false,"given":"Jianyong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.07.025"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476\u20105829.2007.00142.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151649"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.9b00204"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.682736"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2013.2279"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201608936"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8DT00838H"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11050819"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10565\u2010023\u201009827\u20104"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-022-00631-7"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000495897"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/1372494"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2018.08.013"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-020-08798-2"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-018-0011-2"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.736991"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423\u2010022\u201000966\u2010y"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00890"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1232458"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1229963"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2002521"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa2630"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07317"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2020.12.037"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004726"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI96329"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101215"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-016-2012-z"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2007.03.011"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255\u2010019\u20100150\u20108"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/13510002.2017.1416773"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.16926","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T09:31:18Z","timestamp":1748338278000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.16926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,7]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/jgh.16926"],"URL":"https:\/\/doi.org\/10.1111\/jgh.16926","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,7]]},"assertion":[{"value":"2024-12-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}