{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:02:11Z","timestamp":1790240531650,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Capsule endoscopy (CE) is a valuable tool used in the diagnosis of small intestinal lesions. The study aims to systematically review the literature and provide a meta\u2010analysis of the diagnostic accuracy, specificity, sensitivity, and negative and positive predictive values of AI\u2010assisted <jats:sc>CE<\/jats:sc> in the diagnosis of small bowel lesions in comparison to <jats:sc>CE<\/jats:sc>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Literature searches were performed through PubMed, SCOPUS, and EMBASE to identify studies eligible for inclusion. All publications up to 24 November 2024 were included. Original articles (including observational studies and randomized control trials), systematic reviews, meta\u2010analyses, and case series reporting outcomes on AI\u2010assisted <jats:sc>CE<\/jats:sc> in the diagnosis of small bowel lesions were included. The extracted data were pooled, and a meta\u2010analysis was performed for the appropriate variables, considering the clinical and methodological heterogeneity among the included studies. Comprehensive Meta\u2010Analysis v4.0 (Biostat Inc.) was used for the analysis of the data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 14 studies were included in the present study. The mean age of participants across the studies was 54.3\u2009years (SD 17.7), with 55.4% men and 44.6% women. The pooled accuracy for conventional <jats:sc>CE<\/jats:sc> was 0.966 (95% CI: 0.925\u20130.988), whereas for AI\u2010assisted <jats:sc>CE,<\/jats:sc> it was 0.9185 (95% CI: 0.9138\u20130.9233). Conventional <jats:sc>CE<\/jats:sc> exhibited a pooled sensitivity of 0.860 (95% CI: 0.786\u20130.934) compared with AI\u2010assisted <jats:sc>CE<\/jats:sc> at 0.9239 (95% CI: 0.8648\u20130.9870). The positive predictive value for conventional <jats:sc>CE<\/jats:sc> was 0.982 (95% CI: 0.976\u20130.987), whereas AI\u2010assisted <jats:sc>CE<\/jats:sc> had a PPV of 0.8928 (95% CI: 0.7554\u20130.999). The pooled specificity for conventional <jats:sc>CE<\/jats:sc> was 0.998 (95% CI: 0.996\u20130.999) compared with 0.5367 (95% CI: 0.5244\u20130.5492) for AI\u2010assisted <jats:sc>CE<\/jats:sc>. Negative predictive values were higher in AI\u2010assisted <jats:sc>CE<\/jats:sc> at 0.9425 (95% CI: 0.9389\u20130.9462) versus 0.760 (95% CI: 0.577\u20130.943) for conventional <jats:sc>CE<\/jats:sc>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>AI\u2010assisted <jats:sc>CE<\/jats:sc> displays superior diagnostic accuracy, sensitivity, and positive predictive values albeit the lower pooled specificity in comparison with conventional <jats:sc>CE<\/jats:sc>. Its use would ensure accurate detection of small bowel lesions and further enhance their management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16931","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T06:58:38Z","timestamp":1741935518000},"page":"1105-1118","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Artificial Intelligence\u2013Assisted Capsule Endoscopy Versus Conventional Capsule Endoscopy for Detection of Small Bowel Lesions: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1794-2569","authenticated-orcid":false,"given":"Arkadeep","family":"Dhali","sequence":"first","affiliation":[{"name":"Academic Unit of Gastroenterology Sheffield Teaching Hospitals NHS Foundation Trust  Sheffield UK"},{"name":"School of Medicine and Population Health University of Sheffield  Sheffield 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