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Previous studies have identified NLRP3 inflammasome as a class of receptors of intracellular intrinsic immunity. These receptors can be activated by both intrinsic and extracellular danger signals, leading to the release of downstream pro\u2010inflammatory factors, including interleukin IL\u20101\u03b2 and IL\u201018. These vesicles are critical for maintaining host defense. Concurrently, researchers have identified a close relationship between the microbiome, gut\u2013liver axis, and NLRP3 inflammasome with ALD. Consequently, the present study focus on the structure and activation of the NLRP3 inflammasome, the gut\u2013liver axis, and intestinal microecological regulation, as well as the relationship between bile acid metabolism and the gut\u2013liver axis. The objective of this study is to provide a foundation of knowledge and references for the development of targeted therapeutic interventions of ALD that are informed by the dynamic interplay between the NLRP3 inflammasome and the gut\u2013liver axis.<\/jats:p>","DOI":"10.1111\/jgh.16935","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T07:09:02Z","timestamp":1742195342000},"page":"1070-1078","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["NLRP3 and Gut\u2013Liver Axis: New Possibility for the Treatment of Alcohol\u2010Associated Liver Disease"],"prefix":"10.1111","volume":"40","author":[{"given":"Lu","family":"Dong","sequence":"first","affiliation":[{"name":"Dalian key Laboratory of Chronic Disease Research Center Dalian University  Dalian Liaoning Province 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