{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T14:53:29Z","timestamp":1780498409736,"version":"3.54.1"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Vedolizumab (VDZ) is often used in older patients with ulcerative colitis (UC) in clinical practice; however, real\u2010world evidence is still limited, including in those with late\u2010onset UC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This post hoc analysis of a multicenter, retrospective, observational chart review, enrolling 370 patients with UC receiving VDZ between December 2018 and February 2020, compared effectiveness and safety of VDZ among patients \u2265\u200970 (<jats:italic>n<\/jats:italic>\u2009=\u200940) versus &lt;\u200970\u2009years (<jats:italic>n<\/jats:italic>\u2009=\u2009330), and among patients \u2265\u200970\u2009years with and without late\u2010onset UC (age at disease onset: \u2265\u200970 [<jats:italic>n<\/jats:italic>\u2009=\u200913] versus &lt;\u200970\u2009years [<jats:italic>n<\/jats:italic>\u2009=\u200926]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no differences between patients \u2265\u200970 and &lt;\u200970\u2009years in clinical remission rates (week 6: 57.5% vs. 47.6%, <jats:italic>p<\/jats:italic>\u2009=\u20090.9174; week 14: 62.5% vs. 54.8%, <jats:italic>p<\/jats:italic>\u2009=\u20090.1317; week 54: 47.5% vs. 46.4%, <jats:italic>p<\/jats:italic>\u2009=\u20090.8149), primary nonresponse (10.0% vs. 15.5%, <jats:italic>p<\/jats:italic>\u2009=\u20090.6248), loss of response (12.5% vs. 9.4%, <jats:italic>p<\/jats:italic>\u2009=\u20090.5675), or overall safety. Among patients \u2265\u200970\u2009years, the incidence of adverse drug reactions was numerically greater in those with concomitant corticosteroids than in those without. For older patients with and without late\u2010onset UC, week 54 remission rates were 23.1% versus 57.7% (<jats:italic>p<\/jats:italic>\u2009=\u20090.0544); surgery was reported in 3\/13 versus 2\/26 patients and hospitalization in 5\/13 versus 6\/26 patients. One death was reported in patients with late\u2010onset UC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>VDZ effectiveness and safety were similar in patients \u2265\u200970 and &lt;\u200970\u2009years; VDZ may be a suitable treatment option for patients \u2265\u200970\u2009years with UC. Patients with late\u2010onset UC tended to have more frequent surgery\/hospitalization and lower effectiveness than those without, possibly necessitating greater caution when using VDZ.<\/jats:p><jats:p><jats:bold>Trial Registration:<\/jats:bold> Japanese Registry of Clinical Trials registration number: jRCT\u20101080225363<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16936","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T08:25:30Z","timestamp":1747297530000},"page":"1435-1445","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Real\u2010World Effectiveness and Safety of Vedolizumab in Patients \u2265\u200970 Versus &lt;\u200970\u2009Years With Ulcerative Colitis: Multicenter Retrospective Study"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1178-3536","authenticated-orcid":false,"given":"Tadakazu","family":"Hisamatsu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kyorin University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2073-4234","authenticated-orcid":false,"given":"Taku","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Center for Advanced IBD Research and Treatment Kitasato University Kitasato Institute Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Motoya","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center Sapporo\u2010Kosei General Hospital  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3048-7270","authenticated-orcid":false,"given":"Toshimitsu","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3083-9600","authenticated-orcid":false,"given":"Reiko","family":"Kunisaki","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center Yokohama City University Medical Center  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyoshi","family":"Shibuya","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Juntendo University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Matsuura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kyorin University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9796-6930","authenticated-orcid":false,"given":"Sakiko","family":"Hiraoka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Okayama University Hospital  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology IBD Center, Tsujinaka Hospital Kashiwanoha  Kashiwa Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4547-5213","authenticated-orcid":false,"given":"Hiroshi","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology St. Marianna University School of Medicine  Kawasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaoru","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kitasato University School of Medicine  Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noritaka","family":"Takatsu","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center Fukuoka University Chikushi Hospital  Chikushino Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuo","family":"Maemoto","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center Sapporo Higashi Tokushukai Hospital  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Tahara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Saiseikai Utsunomiya Hospital  Utsunomiya Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3716-3386","authenticated-orcid":false,"given":"Keiichi","family":"Tominaga","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Dokkyo Medical University  Mibu Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology NHO Nagoya Medical Center  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuaki","family":"Kuno","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Medicine Fukuoka University Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jovelle\u00a0L.","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Japan Medical Office Takeda Pharmaceutical Company Limited  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Hirose","sequence":"additional","affiliation":[{"name":"Japan Medical Office Takeda Pharmaceutical Company Limited  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Ishiguro","sequence":"additional","affiliation":[{"name":"Japan Medical Office Takeda Pharmaceutical Company Limited  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Cavaliere","sequence":"additional","affiliation":[{"name":"Japan Medical Office Takeda Pharmaceutical Company Limited  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6256-1204","authenticated-orcid":false,"given":"Toshifumi","family":"Hibi","sequence":"additional","affiliation":[{"name":"Center for Advanced IBD Research and Treatment Kitasato University Kitasato Institute Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-020-01296-x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgh3.12612"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000738"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/17562848211023399"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000522569"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.08.060"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2011.02.001"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.109.153973"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215734"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-311079"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-016-0467-6"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2024.00063"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14263"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2012.02.015"},{"key":"e_1_2_10_16_1","first-page":"170","article-title":"Effectiveness and Safety of Vedolizumab in Inflammatory Bowel Disease Patients Aged 60 and Over: An Observational Multicenter UK Experience","volume":"33","author":"Ibraheim H.","year":"2020","journal-title":"Annals of Gastroenterology"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjz203.096"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izab163"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16923"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.2174\/18715206113136660346"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.313"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.01.012"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13294"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.34200"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.07.035"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.06.050"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13466"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.15928"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjv194"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000993"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2022.12.024"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11061421"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15592"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12893-022-01664-2"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0284895"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-56534-4"},{"key":"e_1_2_10_37_1","unstructured":"Ministry of Health Labour and Welfare. \u201cWhite Paper on Health Labour and Welfare 2020 [in Japanese] \u201d2020. Cited 31 Oct 2024. Available from:https:\/\/www.mhlw.go.jp\/stf\/wp\/hakusyo\/kousei\/19\/."}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.16936","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T22:31:57Z","timestamp":1749076317000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.16936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,15]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/jgh.16936"],"URL":"https:\/\/doi.org\/10.1111\/jgh.16936","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,15]]},"assertion":[{"value":"2024-09-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}