{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:11:00Z","timestamp":1787015460277,"version":"build-2736575974"},"reference-count":72,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T00:00:00Z","timestamp":1743379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22H02841"],"award-info":[{"award-number":["JP22H02841"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP24K18903"],"award-info":[{"award-number":["JP24K18903"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002336","name":"Daiichi Sankyo Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is a well\u2010recognized precursor of pancreatic carcinoma. Along with cross\u2010sectional abdominal imaging tests, endoscopic examinations remain the cornerstone in the diagnosis of pancreatic cysts, early detection of IPMN\u2010derived carcinomas, and risk stratification of patients with IPMNs for subsequent surveillance strategies. In particular, endoscopic ultrasound (EUS) facilitates the optimal patient management by providing high\u2010resolution morphological information, and the contrast\u2010enhanced harmonic mode may further enhance diagnostic accuracy. EUS\u2010guided fine\u2010needle aspiration for solid mass and\/or cyst fluid is considered for pathological and molecular examinations for the diagnosis of pancreatic cysts and malignancy. Emerging evidence suggests the usefulness of through\u2010the\u2010needle biopsy and confocal laser microendoscopy in this setting. In addition to the undoubtful diagnostic utility, recent studies have demonstrated the potential effect of endoscopic interventions (i.e., ablation) on the control of IPMNs. Despite the increasing role of endoscopy in the clinical management of IPMNs, there remains a gap in our understanding of how to utilize endoscopy in the personalized care for patients with IPMNs (e.g., the optimal interval of EUS) and the prevention of deaths due to pancreatic carcinomas developing concomitantly with IPMNs.<\/jats:p>\n                  <jats:p>This review summarizes the current evidence on the role of endoscopy in both the diagnostic and therapeutic landscapes of clinical management of IPMNs and identifies key clinical unmet needs that should be addressed in future research. Combined with emerging technologies (e.g., artificial intelligence and high\u2010throughput molecular profiling), endoscopy would offer more effective and tailored management strategies for patients with IPMNs.<\/jats:p>","DOI":"10.1111\/jgh.16938","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T02:05:02Z","timestamp":1743473102000},"page":"1045-1058","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Role of Endoscopy in Clinical Management of Intraductal Papillary Mucinous Neoplasms"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3937-2755","authenticated-orcid":false,"given":"Tsuyoshi","family":"Hamada","sequence":"first","affiliation":[{"name":"Graduate School of Medicine Department of Gastroenterology The University of Tokyo  Tokyo Japan"},{"name":"The Cancer Institute Hospital Department of Hepato\u2010Biliary\u2010Pancreatic Medicine Japanese Foundation for Cancer Research  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Oyama","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine Department of Gastroenterology The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1265-3100","authenticated-orcid":false,"given":"Naminatsu","family":"Takahara","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine Department of Gastroenterology The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7411-1385","authenticated-orcid":false,"given":"Yousuke","family":"Nakai","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine Department of Gastroenterology The University of Tokyo  Tokyo Japan"},{"name":"Institute of Gastroenterology Department of Internal Medicine Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiro","family":"Fujishiro","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine Department of Gastroenterology The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,31]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2309041"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2024.02.041"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2023.12.009"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.08.032"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2024.08.013"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000006383"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.12873"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tige.2024.04.001"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.22454"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000771"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2024.05.043"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1971-1274"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2017.07.007"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.01.015"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2018.14"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-316027"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/deo2.413"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.13257"},{"key":"e_1_2_12_20_1","first-page":"35","article-title":"Contrast\u2010Enhanced Harmonic Endoscopic Ultrasonography for Differential Diagnosis of Pancreatic Cysts","volume":"48","author":"Kamata K.","year":"2016","journal-title":"Endoscopy"},{"key":"e_1_2_12_21_1","first-page":"26","article-title":"Contrast\u2010Enhanced Harmonic Endoscopic Ultrasonography With Time\u2010Intensity Curve Analysis for Intraductal Papillary Mucinous Neoplasms of the Pancreas","volume":"48","author":"Yamamoto N.","year":"2016","journal-title":"Endoscopy"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181a189a8"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2020.06.004"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2023.01.032"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2024-333259"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1443-1661.2010.01063.x"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.169"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1869-0180"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2022.04.019"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2018.04.012"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000002294"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002088"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2023.05.005"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.09.028"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aav4772"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001623"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15398"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.5154"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.14927"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14151587"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2020.01.038"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-2163-8805"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2015.12.033"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16061238"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.12152"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2014.06.021"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2014.10.025"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.06.010"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2022.08.012"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2017.03.002"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2020.12.054"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hbpd.2019.09.004"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2023.12.008"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2024.03.021"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.08.009"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1949-7730"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2023.12.014"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0824-7067"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000002422"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2023.04.003"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.4240\/wjgs.v7.i4.52"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-121459"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2024.04.012"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-022-11704-z"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000006268"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-023-02028-0"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002966"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(23)00064-X"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgh3.12692"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2023-330329"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002178"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.106021"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2023.07.019"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.16938","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T09:31:44Z","timestamp":1748338304000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.16938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,31]]},"references-count":72,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/jgh.16938"],"URL":"https:\/\/doi.org\/10.1111\/jgh.16938","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,31]]},"assertion":[{"value":"2025-01-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}