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Recent years have witnessed a paradigm shift, recognizing diet not only as an influencer in disease development but also as a disease\u2010modifying factor and treatment avenue for IBD. The AGA CPU\u00a0endorses a balanced Mediterranean\u2010style diet, emphasizing the need for personalized recommendations tailored to individual patient characteristics, including disease course, surgical history, and pharmacotherapy.<\/jats:p><jats:p>The implementation of complex nutritional strategies necessitates the involvement of both gastroenterologists and registered dietitians. Guidance for patients and caregivers is available through organizations such as Crohn's and Colitis Canada and Crohn's and Colitis Foundation. While animal models offer valuable insights, the review underscores their limitations in replicating the complexity of IBD biology observed in humans. It advocates for an exploration of nutrigenomics, utilizing molecular tools to analyze how diet\u2010derived bioactive compounds influence gene expression for precision nutrition insights.<\/jats:p><jats:p>Practical challenges in dietary intervention studies, including regional variations and complexities in food handling, require attention for enhanced comparability. Limited data exist on combined dietary and medical therapies, but promising outcomes suggest potential synergies. Precision treatments could develop through an understanding of the function of particular food metabolites in influencing inflammation. The objective of this review is to offer a summary of the present comprehension of diet, serving as both a potential factor contributing to and a therapeutic avenue for IBD.<\/jats:p><jats:p><jats:bold>Clinical Trial Registration:<\/jats:bold> This study is not a part of a clinical trial.<\/jats:p>","DOI":"10.1111\/jgh.16939","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T00:19:40Z","timestamp":1743207580000},"page":"1352-1363","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Understanding Role of Nutrition in Inflammatory Bowel Disease: A Comprehensive Review With Incorporation of AGA Update"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1362-6100","authenticated-orcid":false,"given":"Galvin","family":"Dhaliwal","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Houston\/HCA Houston Healthcare  Kingwood Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8544-9039","authenticated-orcid":false,"given":"Dushyant\u00a0Singh","family":"Dahiya","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology &amp; Motility The University of Kansas School of Medicine  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashvin\u00a0Singh","family":"Dhaliwal","sequence":"additional","affiliation":[{"name":"Department of Graduate Medical Education Dayanand Medical College and Hospital  Ludhiana Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassam","family":"Ali","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology &amp; Nutrition East Carolina University\/Brody School of Medicine  Greenville North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3931-6163","authenticated-orcid":false,"given":"Manesh\u00a0Kumar","family":"Gangwani","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University of Arkansas for Medical Sciences  Little Rock Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fouad","family":"Jaber","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology and Hepatology Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saqr","family":"Alsakarneh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Missouri\u2010Kansas City  Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Islam","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Division of Hepatology University of Missouri School of Medicine  Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umar","family":"Hayat","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Geisinger Wyoming Valley Medical Center  Wilkes Barre Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8936-1870","authenticated-orcid":false,"given":"Bhanu\u00a0Siva\u00a0Mohan","family":"Pinnam","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine John H. 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