{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T23:10:01Z","timestamp":1749078601802,"version":"3.41.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Esophageal squamous cell carcinoma (ESCC) in patients with no history of tobacco smoking or alcohol consumption accounts for approximately 5% of all ESCCs. This study aimed to clarify the clinicopathological features of superficial ESCCs in patients with no history of tobacco smoking or alcohol consumption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical data and pathological features of 108 superficial ESCCs in endoscopic submucosal dissection (ESD) specimens obtained from 102 patients with no history of tobacco smoking or alcohol consumption (NTNA group) were reviewed. For comparison, the clinicopathological features of 767 superficial ESCCs in ESD specimens from 544 patients with history of tobacco smoking and alcohol consumption (TA group) were also reviewed. Factors analyzed included age, sex, synchronous\/metachronous cancer, gastroesophageal reflux disease (GERD), tumor size, tumor site, macroscopic type, Lugol\u2010voiding lesion (LVL) grade, invasion depth, and lymphovascular invasion. LVLs were graded as A (no lesions), B (1\u20139 lesions), and C (&gt;\u20099 lesions).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The univariate analysis revealed that female predominance (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), absence of synchronous\/metachronous cancer (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), grade A LVLs (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), presence of GERD (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), tumor location in the middle thoracic esophagus (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), tumor location at the posterior wall (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), and 0\u2013IIa macroscopic type (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) were significantly more frequently observed in NTNA group than in TA group. Multivariate analysis identified female predominance (OR 68.2, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), LVL grade A (OR 50.6, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and 0\u2013IIa macroscopic type (OR 7.2, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) as significant features in the NTNA group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrated the unique clinicopathological features of ESCCs in patients with NTNA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16946","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T02:09:48Z","timestamp":1743214188000},"page":"1454-1460","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinicopathological Features of Esophageal Squamous Cell Carcinomas in Patients With No History of Tobacco Smoking or Alcohol Consumption"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5606-4985","authenticated-orcid":false,"given":"Yoko","family":"Tateishi","sequence":"first","affiliation":[{"name":"Department of Pathology Yokohama Municipal Citizen's Hospital  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehide","family":"Fukuchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Fujisawa City Hospital  Fujisawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6660-3459","authenticated-orcid":false,"given":"Kingo","family":"Hirasawa","sequence":"additional","affiliation":[{"name":"Division of Endoscopy Yokohama City University Medical Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0246-1594","authenticated-orcid":false,"given":"Shin","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Yokohama City University  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Okudela","sequence":"additional","affiliation":[{"name":"Department of Pathology Saitama Medical University  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiro","family":"Nakanishi","sequence":"additional","affiliation":[{"name":"Department of Pathology H. Lee Moffitt Cancer Center  Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika","family":"Tsunomiya","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miwako","family":"Arima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology AGEO Central General Hospital  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Nemoto","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology and Laboratory Medicine Showa University Northern Yokohama Hospital  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuneo","family":"Oyama","sequence":"additional","affiliation":[{"name":"Division of Endoscopy Saku Central Hospital Advanced Care Center  Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Inayama","sequence":"additional","affiliation":[{"name":"Division of Pathology Yokohama City University Medical Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29210"},{"key":"e_1_2_8_3_1","first-page":"362","article-title":"Tobacco Smoke and Involuntary Smoking","volume":"83","author":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans","year":"2004","journal-title":"IARC Monographs on the Evaluation of Carcinogenic Risks to Humans"},{"key":"e_1_2_8_4_1","first-page":"351","article-title":"Alcohol Consumption and Ethyl Carbamate","volume":"96","author":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans","year":"2010","journal-title":"IARC Monographs on the Evaluation of Carcinogenic Risks to Humans"},{"key":"e_1_2_8_5_1","first-page":"70","article-title":"Personal Habits and Indoor Combustions","volume":"100","author":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans","year":"2012","journal-title":"IARC Monographs on the Evaluation of Carcinogenic Risks to Humans"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2007.01.039"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2002.119287"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0435"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.07.040"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.205724"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2191"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/dow019"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-021-01815-x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-99790-z"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.13631"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000516021"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.7078"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.21037\/acs.2017.03.14"},{"issue":"3","key":"e_1_2_8_19_1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s10388-024-01054-y","article-title":"Japanese Classification of Esophageal cancer, 12th Edition: Part I","volume":"21","author":"Japan Esophageal Society","year":"2024","journal-title":"Esophagus"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v111.pm8698230"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2050.2012.01429.x"},{"key":"e_1_2_8_22_1","first-page":"36","volume-title":"WHO Classification of Digestive System Tumours","author":"Takubo K.","year":"2019"},{"key":"e_1_2_8_23_1","first-page":"112","volume-title":"WHO Classification of Head and Neck Tumours","author":"Reibel J.","year":"2017"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-021-01402-9"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12830"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13831"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.226450"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19960717)67:2<269::AID-IJC19>3.0.CO;2-6"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27824"},{"key":"e_1_2_8_30_1","first-page":"175","article-title":"Association Between Duodenal Contents Reflux and Squamous Cell Carcinoma\u2013Establishment of an Esophageal Cancer Cell Line Derived From the Metastatic Tumor in a Rat Reflux Model","volume":"27","author":"Chen K. 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